Review
Update to RIFM fragrance ingredient safety assessment, myristic acid, CAS Registry Number 544-63-8.
A M Api, A Bartlett, D Belsito, D Botelho, M Bruze, A Bryant-Friedrich + 28 more
ReviewFood and chemical toxicology : an international journal published for the British Industrial Biological Research Association2026
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Research Facts
Update to RIFM fragrance ingredient safety assessment, myristic acid, CAS Registry Number 544-63-8.
A M Api, A Bartlett, D Belsito, D Botelho, M Bruze, A Bryant-Friedrich + 28 more
Review · Moderate · 2026 · Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
Findings

Myristic acid passed safety testing across multiple categories: it's not genotoxic, doesn't trigger skin sensitization at current use levels, and won't cause photoirritant reactions. Exposure levels in products are well below safety thresholds, and it doesn't accumulate in the environment or persist as a toxin.

Design: Review
Evidence: Moderate
Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
Methodology

Researchers evaluated myristic acid against seven safety endpoints (genotoxicity, repeated dose toxicity, reproductive effects, respiratory irritation, photoallergy, skin sensitization, and environmental impact) using a combination of direct testing data and comparisons to chemically similar ingredients.

Funded By

Funding not disclosed in abstract