Review
Per- and polyfluoroalkyl substances (PFAS): immunotoxicity at the primary sites of exposure.
Emma Arnesdotter, Charlotte B A Stoffels, Wiebke Alker, Arno C Gutleb, Tommaso Serchi
ReviewCritical reviews in toxicology2025
Research Facts
Per- and polyfluoroalkyl substances (PFAS): immunotoxicity at the primary sites of exposure.
Emma Arnesdotter, Charlotte B A Stoffels, Wiebke Alker, Arno C Gutleb, Tommaso Serchi
Review · Moderate · 2025
Findings

PFAS chemicals—used in many cosmetics and industrial products—can weaken your immune system, particularly your vaccine response. The research links PFAS exposure to increased asthma, allergies, and inflammatory bowel disease in humans. These effects happen mainly through skin contact, inhalation, and ingestion, though scientists say we need more human studies to fully understand the risks.

Design
Review
Evidence
Moderate
Journal
Critical reviews in toxicology
Methodology

This was a review of existing research, combining human epidemiological studies with animal and lab testing data to examine how PFAS affects immunity at exposure points like skin, lungs, and the gut.

Funded By

Funding not disclosed in abstract