Sodium hyaluronate is safe for use in skincare at concentrations up to 2%. The ingredient showed no toxicity, allergic reactions, or cancer risk in animal studies, and decades of widespread use (especially in injectables) have confirmed it's well-tolerated by humans.

Researchers reviewed toxicity data across multiple animal species using different exposure methods, plus analyzed real-world safety data from clinical use over many years.

Funding not disclosed in abstract