Topical hyaluronic acid effectively hydrates skin and improves signs of aging, with good tolerability across multiple studies. In a 6-month clinical trial, a HA serum used alongside Botox extended the wrinkle-reducing effects of the injection, suggesting HA works well as a supporting ingredient in anti-aging routines.

Researchers reviewed existing literature on topical HA and presented results from a randomized controlled trial where one group used a HA serum twice daily for 24 weeks after Botox injections, while a control group received only Botox.

Funding not disclosed in abstract