RCT
Efficacy and Safety of the Combination of Palmitoylethanolamide, Superoxide Dismutase, Alpha Lipoic Acid, Vitamins B12, B1, B6, E, Mg, Zn and Nicotinamide for 6 Months in People with Diabetic Neuropathy.
Triantafyllos Didangelos, Eleni Karlafti, Evangelia Kotzakioulafi, Parthena Giannoulaki, Zisis Kontoninas, Anastasia Kontana + 4 more
RCTNutrients2024
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Research Facts
Efficacy and Safety of the Combination of Palmitoylethanolamide, Superoxide Dismutase, Alpha Lipoic Acid, Vitamins B12, B1, B6, E, Mg, Zn and Nicotinamide for 6 Months in People with Diabetic Neuropathy.
Triantafyllos Didangelos, Eleni Karlafti, Evangelia Kotzakioulafi, Parthena Giannoulaki, Zisis Kontoninas, Anastasia Kontana + 4 more
RCT · Strong · 2024 · Nutrients
Findings

In people with diabetic nerve damage, this supplement combo reduced pain scores from 20.9 to 13.9 over 6 months—a significant drop. It also improved nerve function markers like nerve conduction speed and vibration sensation, while the placebo group saw no pain improvement and actually got worse on one measure.

Design: RCT
Evidence: Strong
Journal: Nutrients
Methodology

73 people with type 2 diabetes and nerve damage took either the supplement (2 tablets daily) or placebo for 6 months. Researchers measured pain, nerve function, and quality of life using standardized clinical tests.

Funded By

Funding not disclosed in abstract