Review
Safety Assessment of Diethanolamine and Its Salts as Used in Cosmetics.
Monice M Fiume, Bart Heldreth, Wilma F Bergfeld, Donald V Belsito, Ronald A Hill, Curtis D Klaassen + 6 more
ReviewInternational journal of toxicology2017
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Research Facts
Safety Assessment of Diethanolamine and Its Salts as Used in Cosmetics.
Monice M Fiume, Bart Heldreth, Wilma F Bergfeld, Donald V Belsito, Ronald A Hill, Curtis D Klaassen + 6 more
Review ยท Moderate ยท 2017 ยท International journal of toxicology
Findings

Diethanolamine (DEA) and its salts are considered safe for cosmetics when they don't irritate skin. The expert panel reviewed existing safety data and concluded these ingredients are okay to use โ€” but there's a catch: they shouldn't be in products where N-nitroso compounds can form, which is a potential concern if DEA reacts with certain preservatives.

Design: Review
Evidence: Moderate
Journal: International journal of toxicology
Methodology

The Cosmetic Ingredient Review Expert Panel examined animal and clinical safety data for diethanolamine and 16 related salt forms. Since individual safety data wasn't available for each salt, they extrapolated safety conclusions based on previous reports and the fact that these salts break down in water.

Funded By

Funding not disclosed in abstract