Cyclopentasiloxane and related siloxanes showed minimal absorption through skin and no signs of irritation or allergic reactions in testing. The researchers concluded these ingredients are safe at typical use levels in cosmetics, with minimal risk of systemic exposure from skincare products.

This was a safety assessment review by the Cosmetic Ingredient Review Expert Panel, evaluating existing toxicology data on five cyclic siloxane compounds used as conditioning agents in beauty products.

Funding not disclosed in abstract