Review
γ-Mangosteen, an autophagy enhancer, prevents skin-aging via activating KEAP1/NRF2 signaling and downregulating MAPKs/AP-1/NF-κB-mediated MMPs.
Chang-Woo Kim, Md Badrul Alam, Bo-Rim Song, Chang Hyung Lee, Solomon L Kim, Sang-Han Lee
ReviewPhytomedicine : international journal of phytotherapy and phytopharmacology2024
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Research Facts
γ-Mangosteen, an autophagy enhancer, prevents skin-aging via activating KEAP1/NRF2 signaling and downregulating MAPKs/AP-1/NF-κB-mediated MMPs.
Chang-Woo Kim, Md Badrul Alam, Bo-Rim Song, Chang Hyung Lee, Solomon L Kim, Sang-Han Lee
Review · Moderate · 2024 · Phytomedicine : international journal of phytotherapy and phytopharmacology
Findings

Gamma-mangosteen (a compound from mangosteen fruit) protected skin cells from UV damage better than other mangosteen types, boosting the skin's natural antioxidant defenses and reducing collagen-breaking enzymes by 29%. In mice exposed to UVB rays, it reduced signs of skin aging and helped maintain skin elasticity and firmness.

Design: Review
Evidence: Moderate
Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology
Methodology

Researchers tested gamma-mangosteen in human skin cells and on mice using multiple antioxidant assays and UV exposure protocols. They measured specific proteins and enzymes involved in aging to understand how the compound works.

Funded By

Funding not disclosed in abstract