Researchers tested hyaluronic acid at different sizes and found that medium-weight HA (around 30.8 kDa) worked best at reducing damage in low-oxygen environments. This specific size of HA boosted blood vessel growth and skin regeneration in hypoxic tissue — meaning it could help wounds heal better when oxygen is limited.

Scientists created three versions of hyaluronic acid with different molecular weights using enzymatic breakdown, then tested how each one performed in low-oxygen conditions on cells and in live tissue models.

Funding not disclosed in abstract