Daily Use of a Facial Broad Spectrum Sunscreen Over One-Year Significantly Improves Clinical Evaluation of Photoaging

RCT

Randhawa M, Wang S, Leyden JJ, Cula GO, Pagnoni A, Southall MD

RCTDermatologic Surgery2015n=32

Research Facts

Daily Use of a Facial Broad Spectrum Sunscreen Over One-Year Significantly Improves Clinical Evaluation of Photoaging

Randhawa M, Wang S, Leyden JJ, Cula GO, Pagnoni A, Southall MD

RCT · Moderate · 2015

Findings

Daily topical retinol (0.1%) significantly improved crow's feet wrinkles, skin firmness, and overall photoaging after one year

Design

RCT

Sample

n=32

Evidence

Moderate

Journal

Dermatologic Surgery

Methodology

This randomized controlled trial evaluated the long-term anti-aging effects of a topical retinol moisturizer (0.1% retinol) used daily for one year. 32 subjects applied the product to one forearm while the other served as control. Digital image analysis and clinical grading showed statistically significant improvements in fine wrinkles, tactile roughness, mottled hyperpigmentation, and overall photodamage after 52 weeks. Histological analysis confirmed increased glycosaminoglycan and procollagen expression in treated skin. This study provided long-term efficacy data for over-the-counter retinol, supporting its status as the most validated anti-aging ingredient in clean beauty.

Funded By

Johnson & Johnson Consumer Inc.

🧂Conflict of interest.