Efficacy and safety of microencapsulated benzoyl peroxide and microencapsulated tretinoin for the treatment of acne vulgaris: Results from two phase 3 double-blind, randomized, vehicle-controlled studies.

RCT

James Del Rosso, Jeffrey Sugarman, Lawrence Green, Theodore Lain, Ofra Levy-Hacham, Rinat Mizrahi + 1 more

RCTJournal of the American Academy of Dermatology2023

vote to see if the hive agrees

Research Facts

James Del Rosso, Jeffrey Sugarman, Lawrence Green, Theodore Lain, Ofra Levy-Hacham, Rinat Mizrahi + 1 more

RCT · Strong · 2023 · Journal of the American Academy of Dermatology

Findings

This microencapsulated formula combining benzoyl peroxide and tretinoin cleared acne significantly better than a placebo cream over 12 weeks. About 38-39% of people using the treatment saw major improvement in their acne, compared to just 11-15% on placebo. It reduced both inflammatory and noninflammatory lesions by roughly 15-30 more lesions than the control.

Design: RCT

Evidence: Strong

Journal: Journal of the American Academy of Dermatology

Methodology

Researchers split 858 people with moderate to severe acne into two groups: one used the benzoyl peroxide/tretinoin cream once daily for 12 weeks, the other used a placebo. They measured acne improvement using standard dermatology assessments and tracked side effects.

Funded By

Funding not disclosed in abstract