Review
Efficacy of an agonist of α-MSH, the palmitoyl tetrapeptide-20, in hair pigmentation.
S Almeida Scalvino, A Chapelle, N Hajem, E Lati, P Gasser, J-C Choulot + 5 more
ReviewInternational journal of cosmetic science2018
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Research Facts
Efficacy of an agonist of α-MSH, the palmitoyl tetrapeptide-20, in hair pigmentation.
S Almeida Scalvino, A Chapelle, N Hajem, E Lati, P Gasser, J-C Choulot + 5 more
Review · Moderate · 2018 · International journal of cosmetic science
Findings

A lab-created peptide called palmitoyl tetrapeptide-20 (PTP20) showed promise in preventing hair greying by boosting melanin production and reducing oxidative stress in hair follicles. In a small 3-month trial on 15 men with premature greying, daily application of a lotion containing PTP20 increased expression of melanin-producing proteins in plucked hairs.

Design: Review
Evidence: Moderate
Journal: International journal of cosmetic science
Methodology

Researchers tested PTP20 in lab-grown hair follicle cells, isolated human hair samples, and a clinical trial on 15 men. They measured changes in melanin production, oxidative stress markers, and protein expression related to hair pigmentation.

Funded By

Funding not disclosed in abstract