Review
Efficacy and mechanism of retinyl palmitate against UVB-induced skin photoaging.
Peng Shu, Menggeng Li, Nan Zhao, Yuan Wang, Lanyue Zhang, Zhiyun Du
ReviewFrontiers in pharmacology2023
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Research Facts
Efficacy and mechanism of retinyl palmitate against UVB-induced skin photoaging.
Peng Shu, Menggeng Li, Nan Zhao, Yuan Wang, Lanyue Zhang, Zhiyun Du
Review · Moderate · 2023 · Frontiers in pharmacology
Findings

Retinyl palmitate (a vitamin A form) helped protect skin cells from UV damage in lab tests by reducing collagen breakdown, lowering inflammatory markers (IL-6, IL-1β, TNF-α), and boosting cell repair. The research suggests it works through multiple pathways—basically, it's not a one-trick ingredient—but this was cell and tissue testing, not human skin studies.

Design: Review
Evidence: Moderate
Journal: Frontiers in pharmacology
Methodology

Scientists tested retinyl palmitate on skin cells and tissues in a lab, using immunofluorescence imaging, cell migration assays, and genetic analysis to see how it responded to UVB radiation and what mechanisms were involved.

Funded By

Funding not disclosed in abstract