PLLA (a type of injectable) showed promise for reducing facial volume loss and improving skin thickness, with results lasting at least 25 months. It performed better than some alternatives like collagen and PH gel. However, the research quality is considered low—so while early results look good, we need more rigorous studies before declaring it a proven solution. Common side effects were mild: bruising, tenderness, small bumps, and swelling.

Researchers reviewed 11 high-quality clinical trials out of 1,467 studies to assess how well PLLA worked for facial aging and volume loss. They checked each study for bias and reliability.

Funding not disclosed in abstract