Cohort
Associations of coffee/caffeine consumption with postmenopausal breast cancer risk and their interactions with postmenopausal hormone use.
Lusine Yaghjyan, Eric McLaughlin, Amy Lehman, Marian L Neuhouser, Thomas Rohan, Dorothy S Lane + 2 more
CohortEuropean journal of nutrition2022
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Research Facts
Associations of coffee/caffeine consumption with postmenopausal breast cancer risk and their interactions with postmenopausal hormone use.
Lusine Yaghjyan, Eric McLaughlin, Amy Lehman, Marian L Neuhouser, Thomas Rohan, Dorothy S Lane + 2 more
Cohort · Moderate · 2022 · European journal of nutrition
Findings

This large 18-year study of 77,688 postmenopausal women found that drinking coffee showed no link to breast cancer risk. However, higher caffeine intake was mildly associated with increased breast cancer risk overall, and more notably with a specific hormone-sensitive type (ER+/PR+). The difference between coffee and caffeine suggests it's not just the caffeine—other compounds in coffee may have protective effects.

Design: Cohort
Evidence: Moderate
Journal: European journal of nutrition
Methodology

Researchers tracked postmenopausal women from the Women's Health Initiative, recording their coffee and caffeine consumption at the start and monitoring breast cancer diagnoses over 18+ years. They analyzed results by cancer type and hormone receptor status to see if caffeine affected risk differently.

Funded By

Funding not disclosed in abstract