undefined 1
undefined 2
n-Butane
AKA “BUTANE, Diethyl, Methylethylmethane, Butanen, Butani, Butyl hydride, HC 600, A 21 (lowing agent)”
Synthetic
Ingredient Facts
n-Butane
AKA: Diethyl, Methylethylmethane, Butanen, Butani, Butyl hydride, HC 600, A 21 (lowing agent)
Synthetic · Propellant · EWG: 4
Synthetic
Synthetic
Clean
A lightweight propellant that helps deliver the product evenly from the spray bottle onto skin or hair.
Solubility 61 mg/L at 68 °F (NTP, 1992)
Formula
C4H10
Mol. Weight
58.12
CAS #
106-97-8
Form
Liquid
State
Butane is a colorless gas with a faint petroleum-like odor. For transportation it may be stenched. It is shipped as a liquefied gas under its vapor pressure. Contact with the liquid can cause frostbit
See origin →
Functions
Propellant
Dispenses Product
Propels product from container
Traditional Use
A hydrocarbon gas used as an aerosol propellant in cosmetics, developed in the early 20th century. Adopted by the cosmetics industry in the 1950s-1970s as a propellant for spray products.
Skin Types
●all-skin-types
Best For
General
Melanin-Rich Skin
Suitable
Pregnancy & Breastfeeding Safe
Yes
EWG
4
CIR
Safe
Pregnancy
Yes
CIR Safety Findings
Not a Sensitizer
medical-approval
all-shades-safe
Regulatory Status
USA✔ permitted
CANADA✔ permitted
Regulatory Agencies
Dibutyl, Dimethyl, and Diethyl Phthalate and Butyl Benzyl Phthalate.
Andersen FA
International journal of toxicology, 2017
→
RIFM fragrance ingredient safety assessment diethyl succinate, CAS Registry Number 123-25-1.
Api AM, Belsito D, Botelho D, Browne D, Bruze M et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2018
→
Toxicological profile of diethyl phthalate: a vehicle for fragrance and cosmetic ingredients.
Api AM
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2001
→
Distribution and fate of diethyl malonate and diisopropyl fluorophosphate on pig skin in vitro.
Chellquist EM, Reifenrath WG
Journal of pharmaceutical sciences, 1988
→
Final Report of the Safety Assessment of Isobutane, Isopentane, n-Butane, and Propane
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
Final Report on the Safety Assessment of Dibutyl Phthalate, Dimethyl Phthalate, and Diethyl Phthalate
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
Final Report on the Safety Assessment of PPG-9, -25, and -40 Diethylmonium Chloride
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
Isobutane, Butane, Isopentane and Propane
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
Re-evaluation: Dibutyl, Dimethyl and Diethyl Phthalate and Butyl Benzyl Phthalate
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
1,2-Butanediol
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
1,4-Butanediol
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
1,4-Butanediol/Succinic Acid/Adipic Acid/HDI Copolymer
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
2,3-Butanediol
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Bis-Hydroxyethyl Acrylate Poly(1,4-Butanediol)-9/TMHDI Copolymer
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Bis-Isostearyl 1,4-Butanediol/HDI/Hydrogenated Dimer Dilinoleyl Alcohol Copolymer
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Butane
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Diethyl Adipate
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Diethyl Malonate
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Diethyl Phthalate
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Diethyl Sebacate
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Diethyl Succinate
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Diethylene Glycol Diethylhexanoate/Diisononanoate
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Diethylene Glycol Diisononanoate
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Diethylene Glycol/DMAP Acrylamide/PEG-180/HDI Copolymer
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Diethylhexyl Adipate
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Diethylhexyl Carbonate
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Diethylhexyl Dimer Dilinoleate
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Diethylhexyl Fumarate
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Diethylhexyl Malate
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Diethylhexyl Sebacate
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Diethylhexyl Sodium Sulfosuccinate
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Diethylhexyl Succinate
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Diethylpentanediol Dineopentanoate
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Dilinoleic Acid/Butanediol Copolymer
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Glycol Diethylhexanoate
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Isobutane
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Neopentyl Glycol Diethylhexanoate
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
PPG-25 Diethylmonium Chloride
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
PPG-40 Diethylmonium Chloride
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
PPG-9 Diethylmonium Chloride
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Propylene Glycol Diethylhexanoate
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Starch Diethylaminoethyl Ether
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
A review of the metabolism of 1,4-butanediol diglycidyl ether-crosslinked hyaluronic acid dermal fillers.
De Boulle K, Glogau R, Kono T, Nathan M, Tezel A et al.
Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], 2013
→
A review of the metabolism of 1,4-butanediol diglycidyl ether-crosslinked hyaluronic acid dermal fillers.
De Boulle K, Glogau R, Kono T, Nathan M, Tezel A et al.
Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], 2013
→
A review of the metabolism of 1,4-butanediol diglycidyl ether-crosslinked hyaluronic acid dermal fillers.
De Boulle K, Glogau R, Kono T, Nathan M, Tezel A et al.
Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], 2013
→
A review of the metabolism of 1,4-butanediol diglycidyl ether-crosslinked hyaluronic acid dermal fillers.
De Boulle K, Glogau R, Kono T, Nathan M, Tezel A et al.
Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], 2013
→
1,2-Butanediol
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
1,4-Butanediol
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
2,3-Butanediol
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Butane
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Diethyl Malonate
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Diethyl Phthalate
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Diethyl Sebacate
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Diethyl Succinate
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Diethylene Glycol Diethylhexanoate/Diisononanoate
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Diethylhexyl Adipate
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Diethylhexyl Carbonate
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Diethylhexyl Fumarate
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Diethylhexyl Sebacate
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Diethylhexyl Succinate
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Dilinoleic Acid/Butanediol Copolymer
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Glycol Diethylhexanoate
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Isobutane
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Neopentyl Glycol Diethylhexanoate
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
PPG-9 Diethylmonium Chloride
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Propylene Glycol Diethylhexanoate
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
1,2-Epoxybutane
Health Canada
Health Canada Cosmetic Ingredient Hotlist
→
2-(4-Allyl-2-methoxyphenoxy)-N,N-diethylacetamide and its salts
Health Canada
Health Canada Cosmetic Ingredient Hotlist
→
2,3-Dichloro-2-methylbutane
Health Canada
Health Canada Cosmetic Ingredient Hotlist
→
3-Diethylaminopropyl cinnamate
Health Canada
Health Canada Cosmetic Ingredient Hotlist
→
Butane
Health Canada
Health Canada Cosmetic Ingredient Hotlist
→
Butanilicaine and its salts
Health Canada
Health Canada Cosmetic Ingredient Hotlist
→
Diethyl 4-nitrophenyl phosphate
Health Canada
Health Canada Cosmetic Ingredient Hotlist
→
Diethyl maleate
Health Canada
Health Canada Cosmetic Ingredient Hotlist
→
Diethyl sulfate
Health Canada
Health Canada Cosmetic Ingredient Hotlist
→
Diethyl toluamide
Health Canada
Health Canada Cosmetic Ingredient Hotlist
→
Diethylene glycol
Health Canada
Health Canada Cosmetic Ingredient Hotlist
→
Diethylhexyl Adipate
Health Canada
Health Canada Cosmetic Ingredient Hotlist
→
Diethylhexyl phthalate
Health Canada
Health Canada Cosmetic Ingredient Hotlist
→
Isobutane
Health Canada
Health Canada Cosmetic Ingredient Hotlist
→
Efficacy of an emollient containing diethylene glycol/dilinoleic acid copolymer for the treatment of dry skin and pruritus in patients with senile xer
Izumi R, Negi O, Suzuki T, Tominaga M, Kamo A et al.
Journal of cosmetic dermatology, 2017
→
Prospects on bio-based 2,3-butanediol and acetoin production: Recent progress and advances.
Maina S, Prabhu AA, Vivek N, Vlysidis A, Koutinas A et al.
Biotechnology advances, 2022
→
Permeation Enhancer in Microemulsions and Microemulsion-Based Gels: A Comparison of Diethylene Glycol Monoethyl Ether and Oleyl Alcohol.
Pandey S, Baki G
Gels (Basel, Switzerland), 2025
→
Metabolic Engineering of Escherichia coli for De Novo Production of 1,2-Butanediol.
Qin N, Zhu F, Liu Y, Liu D, Chen Z
ACS synthetic biology, 2024
→
Combined effect of silver nanoparticles and aluminium chloride, butylparaben or diethylphthalate on the malignancy of MDA-MB-231 breast cancer cells a
Roszak J, Smok-Pieniążek A, Jeżak K, Domeradzka-Gajda K, Grobelny J et al.
Toxicology in vitro : an international journal published in association with BIBRA, 2020
→
Scientific Advice on the safety of Diethylamino Hydroxybenzoyl Hexyl Benzoate - DHHB – S83 (CAS/EC No. 302776-68-7/443-860-6)
Scientific Committee on Consumer Safety (SCCS)
European Commission — SCCS
→
Isobutane, Isopentane, Butane, and Propane.
Tucker R, Bergfeld WF, Belsito DV, Cohen DE, Klaassen CD et al.
International journal of toxicology, 2025
→
Isobutane, Isopentane, Butane, and Propane.
Tucker R, Bergfeld WF, Belsito DV, Cohen DE, Klaassen CD et al.
International journal of toxicology, 2025
→
Isobutane, Isopentane, Butane, and Propane.
Tucker R, Bergfeld WF, Belsito DV, Cohen DE, Klaassen CD et al.
International journal of toxicology, 2025
→
Verified Feb 2026
Data: PubChem · CosIng · EWG · CIR