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2-Amino-6-Chloro-4-Nitrophenol
AKA “Phenol, 6-Chloro-4-nitro-2-aminophenol, RODOL 9R BASE, COLOREX 2A6C4NP, DTXCID7023855, RefChem:85305”
Synthetic
Ingredient Facts
2-Amino-6-Chloro-4-Nitrophenol
AKA: 6-Chloro-4-nitro-2-aminophenol, RODOL 9R BASE, COLOREX 2A6C4NP, DTXCID7023855, RefChem:85305
Synthetic · Hair Dyeing · EWG: 6
Synthetic
Synthetic
Clean
A hair color agent that helps create and set vibrant dye shades. Used in permanent hair coloring formulas to deliver long-lasting color results.
Formula
C6H5ClN2O3
Mol. Weight
188.57
CAS #
6358-09-4
Form
Powder
See origin →
Functions
Hair Dyeing
Colors Hair
Traditional Use
A synthetic hair dye intermediate developed to provide specific color nuances in oxidative hair coloring. The chlorine substituent was added to modify color development and stability.
Skin Types
●all-skin-types
Best For
General
Melanin-Rich Skin
Suitable
Pregnancy & Breastfeeding Safe
No
EWG
6
CIR
Safe w/Qualifications
Pregnancy
No
CIR Safety Findings
ewg-6
medical-approval
all-shades-safe
Phototoxicity Concern
Concentration Guide
2.0%
0%3%
Reg. Limit
EU regulatory limit: 2.0%. (a) To be printed on the label: The mixing ratio. ‘ Hair colourants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of... Source: EU Cosmetics Regulation (EC) 1223/2009, Annex III (Restricted Substances), Entry 252.
Regulatory Status
USA✔ permitted
EU✔ permitted
JAPAN✔ permitted
CANADA✔ permitted
Final Amended Report on the Safety Assessment of p-Methylaminophenol Sulfate and p-Methylaminophenol
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
Final Report on the Safety Assessment of 2-Amino-6-Chloro-4-Nitrophenol and 2-Amino-6-Chloro-4-Nitrophenol Hydrochloride
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
Final Report on the Safety Assessment of 2-Methyl-5-Hydroxyethylaminophenol
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
Final Report on the Safety Assessment of 2,4-Diaminophenol and 2,4-Diaminophenol Dihydrochloride
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
Final Report on the Safety Assessment of 6-Amino-m-Cresol, 6-Amino-o-Cresol, 4-Amino-m-Cresol, 5-Amino-4-Chloro-o-Cresol, 5-Amino-6-Chloro-o-Cresol and 4-Chloro-2-Aminophenol
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
Final Report on the Safety Assessment of Amino Nitrophenols Used in Hair Dyes
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
Final Report on the Safety Assessment of p-Aminophenol, m-Aminophenol, and o-Aminophenol
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
Final Report on the Safety Assessment of p-Methylaminophenol Sulfate
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
Final Report on the Safety Assessment of Zinc Phenolsulfonate
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
Final Report: Amended Safety Assessment of 4-Chloro-2-Aminophenol as Used in Cosmetics
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
Final Report: Safety Assessment of Sodium Benzotriazolyl Butylphenol Sulfonate as Used in Cosmetics
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
Final Report: Safety Assessment of Tetrabromophenol Blue as Used in Cosmetics
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
Zinc Phenolsulfonate
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
2-Amino-5-Nitrophenol
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
2-Amino-6-Chloro-4-Nitrophenol
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
2-Methyl-5-Hydroxyethylaminophenol
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
3-Nitro-p-Hydroxyethylaminophenol
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
4-Amino-3-Nitrophenol
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
4-Hydroxypropylamino-3-Nitrophenol
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Lingonberry (Vaccinium vitis-idaea L.) Fruit Phenolic Bio...
Pirjo Pärnänen, Sari Niikko, Hanna Lähteenmäki, Ismo T Räisänen, Taina Tervahartiala, Timo Sorsa + 1 more
Microorganisms, 2024
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Verified Feb 2026
Data: PubChem · CosIng · EWG · CIR