4-Nitro-o-Phenylenediamine
AKA “2-phenylenediamine, 2-Diamino-4-nitrobenzene, 2-Amino-4-nitroaniline, 2-diaminobenzene, p-Nitro-o-phenylenediamine, 4-Diaminonitrobenzene, 2-Benzenediamine, 2-benzenediamine
Synthetic
Ingredient Facts
4-Nitro-o-Phenylenediamine
AKA: 2-phenylenediamine, 2-Diamino-4-nitrobenzene, 2-Amino-4-nitroaniline, 2-diaminobenzene, P-Nitro-o-phenylenediamine, 4-Diaminonitrobenzene, 2-Benzenediamine, 2-benzenediamine
Synthetic · Hair Dyeing · EWG: 4
Synthetic
Safety Concern
Synthetic
Clean
A synthetic colorant that helps create long-lasting hair dyes. It works as a base ingredient in permanent color formulas to develop rich, vibrant shades.
Solubility less than 1 mg/mL at 68.9 °F (NTP, 1992)
Formula
C6H7N3O2
Mol. Weight
153.14
CAS #
99-56-9
Form
Liquid
State
4-nitro-o-phenylenediamine appears as dark red needles or red solid. (NTP, 1992)
See origin →
Functions
Hair Dyeing
Reduces Inflammation
Antioxidant Protection
Fights Bacteria
Colors Hair
Traditional Use
Synthetic azo dye developed in the early 20th century for use as a hair colorant. Part of the family of coal tar-derived compounds that revolutionized permanent hair color formulation.
Skin Types
all-skin-types
Best For
General
Melanin-Rich Skin
Suitable
Pregnancy & Breastfeeding Safe
No
Allergen Warning
⚠️ PPD (Hair Dye)
EWG
4
CIR
Unsafe
Pregnancy
No
CIR Safety Findings
Not a Sensitizer
medical-approval
all-shades-safe
Regulatory Status
USArestricted
EUpermitted
JAPANpermitted
CANADArestricted
Verified Feb 2026
Data: PubChem · CosIng · EWG · CIR