5-Amino-4-Chloro-o-Cresol
AKA “Phenol, 2-Methyl-4-chloro-5-aminophenol, 2-Methyl-5-amino-4-chlorophenol, 3-Amino-4-chloro-6-methylphenol, RefChem:532310”
Synthetic
Ingredient Facts
5-Amino-4-Chloro-o-Cresol
AKA: Phenol, 2-Methyl-4-chloro-5-aminophenol, 2-Methyl-5-amino-4-chlorophenol, 3-Amino-4-chloro-6-methylphenol, RefChem:532310
Synthetic · Hair Dyeing · EWG: 4
Synthetic
Synthetic
Clean
A synthetic colorant that helps hair dyes achieve vibrant, long-lasting color. Works as a key component in permanent hair color formulations.
Formula
C7H8ClNO
Mol. Weight
157.60
CAS #
110102-86-8
Form
Powder
See origin →
Functions
Hair Dyeing
Colors Hair
Traditional Use
Synthetic hair dye intermediate developed mid-20th century as part of modern oxidative hair coloring systems. Designed to replace natural plant-based dyes with more stable, permanent color options.
Skin Types
●all-skin-types
Best For
General
Melanin-Rich Skin
Suitable
Pregnancy & Breastfeeding Safe
No
EWG
4
CIR
Safe w/Qualifications
Pregnancy
No
CIR Safety Findings
Not an Irritant
medical-approval
all-shades-safe
Concentration Guide
Dermal absorption: 1.05%. Source: CIR Safety Assessment (CIR Seq 908).
Regulatory Agencies
Final Amended Report on the Safety Assessment of p-Methylaminophenol Sulfate and p-Methylaminophenol
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
Final Report on the Safety Assessment of 2-Amino-6-Chloro-4-Nitrophenol and 2-Amino-6-Chloro-4-Nitrophenol Hydrochloride
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
Final Report on the Safety Assessment of 2-Methyl-5-Hydroxyethylaminophenol
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
Final Report on the Safety Assessment of 2,4-Diaminophenol and 2,4-Diaminophenol Dihydrochloride
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
Final Report on the Safety Assessment of 6-Amino-m-Cresol, 6-Amino-o-Cresol, 4-Amino-m-Cresol, 5-Amino-4-Chloro-o-Cresol, 5-Amino-6-Chloro-o-Cresol and 4-Chloro-2-Aminophenol
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
Final Report on the Safety Assessment of Amino Nitrophenols Used in Hair Dyes
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
Final Report on the Safety Assessment of p-Aminophenol, m-Aminophenol, and o-Aminophenol
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
Final Report on the Safety Assessment of p-Methylaminophenol Sulfate
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
Final Report on the Safety Assessment of Zinc Phenolsulfonate
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
Final Report: Amended Safety Assessment of 4-Chloro-2-Aminophenol as Used in Cosmetics
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
Final Report: Amended Safety Assessment of 5-Amino-4-Chloro-o-Cresol and 5-Amino-4-Chloro-o-Cresol HCl as Used in Cosmetics
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
Final Report: Safety Assessment of Sodium Benzotriazolyl Butylphenol Sulfonate as Used in Cosmetics
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
Final Report: Safety Assessment of Tetrabromophenol Blue as Used in Cosmetics
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
Zinc Phenolsulfonate
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
2-Amino-5-Nitrophenol
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
2-Amino-6-Chloro-4-Nitrophenol
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
2-Methyl-5-Hydroxyethylaminophenol
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
3-Nitro-p-Hydroxyethylaminophenol
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
4-Amino-3-Nitrophenol
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
4-Hydroxypropylamino-3-Nitrophenol
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
Lingonberry (Vaccinium vitis-idaea L.) Fruit Phenolic Bio...
Pirjo Pärnänen, Sari Niikko, Hanna Lähteenmäki, Ismo T Räisänen, Taina Tervahartiala, Timo Sorsa + 1 more
Microorganisms, 2024
Verified Feb 2026
Data: PubChem · CosIng · EWG · CIR