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Betaine
AKA “glycine betaine, oxyneurine, Trimethylglycine, lycine, Abromine, Trimethylglycocoll, Glycocoll betaine, Glycylbetaine”
Synthetic
Ingredient Facts
Betaine
AKA: Glycine betaine, Oxyneurine, Trimethylglycine, Lycine, Abromine, Trimethylglycocoll, Glycocoll betaine, Glycylbetaine
Synthetic · Humectant · EWG: 3
Plant-Derived Synthetic
Humectant
Skin Conditioner
Amino Acid
Synthetic
Clean
A naturally derived humectant that draws moisture into skin and hair, helping them stay hydrated and soft throughout the day.
Effective at 4.91%
Solubility Soluble
Formula
C5H11NO2
Mol. Weight
117.15
CAS #
107-43-7
Form
Liquid
See origin →
Functions
Conditioning
A catch-all term for ingredients that improve how skin looks and feels — softer, smoother, more supple. The workhorse behind most moisturizers.
Humectant
A moisture magnet. Pulls water from the air and deeper skin layers up to the surface to keep skin plump and hydrated.
Draws water to skin
Traditional Use
Insufficient information to provide a meaningful historical or traditional use description; this appears to be an incomplete or incorrectly formatted ingredient designation.
Skin Types
●all-skin-types
Best For
General
Melanin-Rich Skin
Suitable
EWG
3
CIR
Insufficient
Pregnancy
—
CIR Safety Findings
Not a Sensitizer
all-shades-safe
Concentration Guide
0.015%
9.8%
0%14%
Effective Range
CIR reported use: 0.53-9.8 | 0.015-8.8
Regulatory Status
USAunder review
CANADA✔ permitted
Regulatory Agencies
Contact allergy related to TEA-PEG-3 cocamide sulfate and cocamidopropyl betaine in a shampoo.
Andersen KE, Roed-Petersen J, Kamp P
Contact dermatitis, 1984
→
Contact allergy related to TEA-PEG-3 cocamide sulfate and cocamidopropyl betaine in a shampoo.
Andersen KE, Roed-Petersen J, Kamp P
Contact dermatitis, 1984
→
Allergic contact dermatitis to coco betaine in a beard cleanser.
Badaoui A
Contact dermatitis, 2024
→
Allergic contact dermatitis to coco betaine in a beard cleanser.
Badaoui A
Contact dermatitis, 2024
→
Final Report of the Cosmetic Ingredient Review Expert Panel on the Safety Assessment of Cocamidopropyl Betaine (CAPB)
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
Final Report on the Safety Assessment of Cocamidopropyl Betaine
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
Safety Assessment of Alkyl Betaines as Used in Cosmetics
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
Almondamidopropyl Betaine
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Apricotamidopropyl Betaine
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Avocadamidopropyl Betaine
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Babassuamidopropyl Betaine
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Behenamidopropyl Betaine
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Behenyl Betaine
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Canolamidopropyl Betaine
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Capryl/Capramidopropyl Betaine
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Capryloyl Glycine
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Cetyl Betaine
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Cocamidopropyl Betaine
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Coco-Betaine
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Coco/Oleamidopropyl Betaine
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Coco/Sunfloweramidopropyl Betaine
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Cupuassuamidopropyl Betaine
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Decyl Betaine
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Glycine
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Glycine Max (Soybean) Callus Culture
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Glycine Max (Soybean) Callus Culture Extract
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Glycine Max (Soybean) Callus Extract
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Glycine Max (Soybean) Fiber
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Glycine Max (Soybean) Flower/Leaf/Stem Juice
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Glycine Max (Soybean) Leaf Cell Extract
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Glycine Max (Soybean) Leaf Extract
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Glycine Max (Soybean) Phytoplacenta Conditioned Media
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Glycine Max (Soybean) Phytoplacenta Extract
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Glycine Max (Soybean) Polypeptide
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Glycine Max (Soybean) Pulp
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Glycine Max (Soybean) Seed Extract
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Glycine Max (Soybean) Seed Powder
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Glycine Max (Soybean) Seedcake Extract
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Glycine Max (Soybean) Seedcoat Extract
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Glycine Max (Soybean) Sprout Extract
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Glycine Soja (Soybean) Extract
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Glycine Soja (Soybean) Fiber
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Glycine Soja (Soybean) Flour
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Glycine Soja (Soybean) Germ Extract
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Glycine Soja (Soybean) Hull
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Glycine Soja (Soybean) Lipids
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Glycine Soja (Soybean) Oil Unsaponifiables
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Glycine Soja (Soybean) Peptide
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Glycine Soja (Soybean) Phytoplacenta Extract
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Glycine Soja (Soybean) Protein
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Glycine Soja (Soybean) Seed
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Glycine Soja (Soybean) Seed Extract
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Glycine Soja (Soybean) Seed Powder
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Glycine Soja (Soybean) Seed Water
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Glycine Soja (Soybean) Seedcake Extract
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Glycine Soja (Soybean) Sprout Extract
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Glycine Soja (Soybean) Sterols
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Hydrogenated Tallow Betaine
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Isostearamidopropyl Betaine
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Lauramidopropyl Betaine
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Lauryl Betaine
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Meadowfoamamidopropyl Betaine
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Methacryloyl Ethyl Betaine/Acrylates Copolymer
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Milkamidopropyl Betaine
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Minkamidopropyl Betaine
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Myristamidopropyl Betaine
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Myristyl Betaine
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Oatamidopropyl Betaine
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Oleamidopropyl Betaine
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Oleyl Betaine
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Olivamidopropyl Betaine
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Palm Kernelamidopropyl Betaine
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Palmamidopropyl Betaine
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Palmitamidopropyl Betaine
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Palmitoyl Glycine
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Ricinoleamidopropyl Betaine
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Sesamidopropyl Betaine
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Shea Butteramidopropyl Betaine
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Soyamidopropyl Betaine
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Stearamidopropyl Betaine
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Stearyl Betaine
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Tallow Betaine
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Tallowamidopropyl Betaine
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Undecylenamidopropyl Betaine
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Undecylenoyl Glycine
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Wheat Germamidopropyl Betaine
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Antifungal Mechanism of Action of Lauryl Betaine Against Skin-Associated Fungus Malassezia restricta.
Do E, Lee HG, Park M, Cho YJ, Kim DH et al.
Mycobiology, 2019
→
Babassuamidopropyl Betaine
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Betaine
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Capryl/Capramidopropyl Betaine
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Capryloyl Glycine
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Cetyl Betaine
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Cocamidopropyl Betaine
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Coco-Betaine
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Glycine
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Glycine Soja (Soy) Peptides
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Glycine Soja (Soybean) Flour
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Glycine Soja (Soybean) Germ Extract
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Glycine Soja (Soybean) Lipids
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Glycine Soja (Soybean) Oil Unsaponifiables
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Glycine Soja (Soybean) Phytoplacenta Extract
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Glycine Soja (Soybean) Protein
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Glycine Soja (Soybean) Seed
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Glycine Soja (Soybean) Seed Extract
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Glycine Soja (Soybean) Sprout Extract
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Glycine Soja (Soybean) Sterols
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Glycine Soja Soybean Oil
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Lauramidopropyl Betaine
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Lauryl Betaine
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Meadowfoamamidopropyl Betaine
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Methacryloyl Ethyl Betaine/Acrylates Copolymer
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Myristamidopropyl Betaine
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Myristyl Betaine
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Oleamidopropyl Betaine
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Oleyl Betaine
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Olivamidopropyl Betaine
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Palmitoyl Glycine
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Shea Butteramidopropyl Betaine
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Soyamidopropyl Betaine
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Undecylenamidopropyl Betaine
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Undecylenoyl Glycine
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Wheat Germamidopropyl Betaine
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Impact of Salix mucronata bark and betaine as natural alleviators on semen quality, serum biochemistry, and oxidative capacity in heat-stressed rabbit
Farag MFM, Daader AH, El-Darawany AA, Bahgat LB, Al-Marakby KM
Tropical animal health and production, 2025
→
Safety assessment of cocamidopropyl betaine, a cosmetic ingredient.
Kim D, Seok JK, Kim M, Choi S, Hong J et al.
Toxicological research, 2024
→
Capryloyl glycine: A polyfunctional cosmetic ingredient and potential skin sensitizer.
Mangodt EA, Dendooven E, De Fré C, Lambert J, Aerts O
Contact dermatitis, 2019
→
Surfactant Penetration into Human Skin from Sodium Dodecyl Sulfate and Lauramidopropyl Betaine Mixtures.
Morris SAV, Xu L, Ananthapadmanabhan KP, Kasting GB
Langmuir : the ACS journal of surfaces and colloids, 2021
→
2-Mercaptonicotinoyl glycine, a new potent melanogenesis ...
Peggy Sextius, Emilie Warrick, Amélie Prévot-Guéguiniat, Guillaume Lereaux, Florence Boirre, Ludwig Baux + 8 more
Pigment cell & melanoma research, 2024
→
2-Mercaptonicotinoyl glycine, a new potent melanogenesis ...
Peggy Sextius, Emilie Warrick, Amélie Prévot-Guéguiniat, Guillaume Lereaux, Florence Boirre, Ludwig Baux + 8 more
Pigment cell & melanoma research, 2024
→
Glycine soja Leaf and Stem Extract Ameliorates Atopic Dermatitis-like Skin Inflammation by Inhibiting JAK/STAT Signaling.
Sung YY, Kim M, Kim DS, Son E
International journal of molecular sciences, 2025
→
Glycine soja Leaf and Stem Extract Ameliorates Atopic Dermatitis-like Skin Inflammation by Inhibiting JAK/STAT Signaling.
Sung YY, Kim M, Kim DS, Son E
International journal of molecular sciences, 2025
→
Glycine soja Leaf and Stem Extract Ameliorates Atopic Dermatitis-like Skin Inflammation by Inhibiting JAK/STAT Signaling.
Sung YY, Kim M, Kim DS, Son E
International journal of molecular sciences, 2025
→
Occupational contact allergy to cocamidopropyl betaine and its impurities.
Suuronen K, Pesonen M, Aalto-Korte K
Contact dermatitis, 2012
→
Verified Feb 2026
Data: PubChem · CosIng · EWG · CIR