Brucine
AKA “Brucine sulfate, Brucine sulphate, Brucine sulfate anhydrous, Brucine sulphate anhydrous, NSC-463, Strychnidin-10-one, sulfate (2:1), 11-DIMETHOXYSTRYCHNINE SULFATE
Synthetic
Ingredient Facts
Brucine
AKA: Brucine sulfate, Brucine sulphate, Brucine sulfate anhydrous, Brucine sulphate anhydrous, NSC-463, Strychnidin-10-one, Sulfate (2:1), 11-DIMETHOXYSTRYCHNINE SULFATE
Synthetic · Antimicrobial · EWG: 5
Synthetic
Preservative
Synthetic
Clean
A denaturant that helps stabilize and preserve the formula, ensuring your product stays fresh and effective from first use to last.
Formula
C46H54N4O12S
Mol. Weight
887.00
CAS #
4845-99-2
Form
Liquid
State
Off-white powder; [Sigma-Aldrich MSDS]
See origin →
Functions
Denaturant
Antimicrobial
Keeps your product from growing bacteria, mold, or yeast. Without these, that jar of cream becomes a petri dish in about a week.
Preservative
Keeps your product from growing bacteria, mold, or yeast. Without these, that jar of cream becomes a petri dish in about a week.
Makes Alcohol Undrinkable
Reduces Inflammation
Locks In Moisture
Traditional Use
An alkaloid compound extracted from the Strychnos nux-vomica tree, traditionally used in Chinese and Ayurvedic medicine for pain relief and inflammation. Its use in modern cosmetics is minimal and primarily historical.
Skin Types
all-skin-types
Best For
General
Melanin-Rich Skin
Suitable
Pregnancy & Breastfeeding Safe
No
EWG
5
CIR
Insufficient
Pregnancy
No
CIR Safety Findings
Not a Sensitizer
medical-approval
all-shades-safe
Regulatory Status
USAunder review
EUpermitted
JAPANpermitted
CANADApermitted
Verified Feb 2026
Data: PubChem · CosIng · EWG · CIR