Brucine Sulfate
AKA “Brucine sulphate, Brucine sulfate anhydrous, Brucine sulphate anhydrous, NSC-463, Strychnidin-10-one, sulfate (2:1), 11-DIMETHOXYSTRYCHNINE SULFATE, RefChem:1080193
Synthetic
Ingredient Facts
Brucine sulfate
AKA: Brucine sulphate, Brucine sulfate anhydrous, Brucine sulphate anhydrous, NSC-463, Strychnidin-10-one, Sulfate (2:1), 11-DIMETHOXYSTRYCHNINE SULFATE, RefChem:1080193
Synthetic · Antimicrobial · EWG: 2
Synthetic
Preservative
Synthetic
Clean
Brucine Sulfate is a denaturant that helps stabilize and preserve the formula, ensuring your product stays fresh and effective throughout its shelf life.
Formula
C46H54N4O12S
Mol. Weight
887.00
CAS #
4845-99-2
Form
Powder
State
Off-white powder; [Sigma-Aldrich MSDS]
See origin →
Functions
Denaturant
Antimicrobial
Keeps your product from growing bacteria, mold, or yeast. Without these, that jar of cream becomes a petri dish in about a week.
Preservative
Keeps your product from growing bacteria, mold, or yeast. Without these, that jar of cream becomes a petri dish in about a week.
Makes Alcohol Undrinkable
Fights Bacteria
Antioxidant Protection
Reduces Inflammation
Traditional Use
A salt form of the plant alkaloid brucine developed for medicinal applications rather than cosmetics. It has no significant traditional cosmetic use history.
Skin Types
all-skin-types, gentle
Best For
General
Melanin-Rich Skin
Suitable
Pregnancy & Breastfeeding Safe
No
EWG
2
CIR
Insufficient
Pregnancy
No
CIR Safety Findings
Not a Sensitizer
ewg-2
medical-approval
pregnancy-nursing-safe
all-shades-safe
Regulatory Status
USAunder review
EUpermitted
JAPANpermitted
CANADApermitted
Verified Feb 2026
Data: PubChem · CosIng · EWG · CIR