Butyl Thioglycolate
AKA “Butyl mercaptoacetate, Butyl 2-mercaptoacetate, Acetic acid, butyl ester, EINECS 233-156-5, NSC 65453”
Synthetic
Ingredient Facts
Butyl thioglycolate
AKA: Butyl mercaptoacetate, Butyl 2-mercaptoacetate, Acetic acid, Butyl ester, EINECS 233-156-5, NSC 65453
Synthetic · Hair Waving Or Straightening · EWG: 4
Synthetic
Synthetic
Clean
Helps relax or curl hair by gently breaking and reforming its structure, making waves or straightening treatments possible.
Formula
C6H12O2S
Mol. Weight
148.23
CAS #
10047-28-6
Form
Liquid
See origin →
Functions
Hair Waving Or Straightening
Reducing Agent
Anti-Inflammatory
Boosts Collagen
Wound Healing
Changes hair texture
Traditional Use
Synthetic reducing agent developed in the mid-20th century for hair permanent wave and depilatory products. Created to break disulfide bonds in hair and dissolve protein structures for chemical hair treatment.
Skin Types
●all-skin-types
Best For
General
Melanin-Rich Skin
Suitable
Pregnancy & Breastfeeding Safe
Caution
Final amended report on the safety assessment of Ammonium Thioglycolate, Butyl Thioglycolate, Calcium Thioglycolate, Ethanolamine Thioglycolate, Ethyl
Burnett CL, Bergfeld WF, Belsito DV, Klaassen CD, Marks JG Jr et al.
International journal of toxicology, 2009
Final amended report on the safety assessment of Ammonium Thioglycolate, Butyl Thioglycolate, Calcium Thioglycolate, Ethanolamine Thioglycolate, Ethyl
Burnett CL, Bergfeld WF, Belsito DV, Klaassen CD, Marks JG Jr et al.
International journal of toxicology, 2009
Final amended report on the safety assessment of Ammonium Thioglycolate, Butyl Thioglycolate, Calcium Thioglycolate, Ethanolamine Thioglycolate, Ethyl
Burnett CL, Bergfeld WF, Belsito DV, Klaassen CD, Marks JG Jr et al.
International journal of toxicology, 2009
Final amended report on the safety assessment of Ammonium Thioglycolate, Butyl Thioglycolate, Calcium Thioglycolate, Ethanolamine Thioglycolate, Ethyl
Burnett CL, Bergfeld WF, Belsito DV, Klaassen CD, Marks JG Jr et al.
International journal of toxicology, 2009
Final amended report on the safety assessment of Ammonium Thioglycolate, Butyl Thioglycolate, Calcium Thioglycolate, Ethanolamine Thioglycolate, Ethyl
Burnett CL, Bergfeld WF, Belsito DV, Klaassen CD, Marks JG Jr et al.
International journal of toxicology, 2009
Final amended report on the safety assessment of Ammonium Thioglycolate, Butyl Thioglycolate, Calcium Thioglycolate, Ethanolamine Thioglycolate, Ethyl
Burnett CL, Bergfeld WF, Belsito DV, Klaassen CD, Marks JG Jr et al.
International journal of toxicology, 2009
Final amended report on the safety assessment of Ammonium Thioglycolate, Butyl Thioglycolate, Calcium Thioglycolate, Ethanolamine Thioglycolate, Ethyl
Burnett CL, Bergfeld WF, Belsito DV, Klaassen CD, Marks JG Jr et al.
International journal of toxicology, 2009
Final amended report on the safety assessment of Ammonium Thioglycolate, Butyl Thioglycolate, Calcium Thioglycolate, Ethanolamine Thioglycolate, Ethyl
Burnett CL, Bergfeld WF, Belsito DV, Klaassen CD, Marks JG Jr et al.
International journal of toxicology, 2009
Safety Assessment of Tetrasodium Glutamate Diacetate and Beta-Alanine Diacetic Acid as Used in Cosmetics.
Burnett CL, Bergfeld WF, Belsito DV, Cohen DE, Klaassen CD et al.
International journal of toxicology, 2025
Safety Assessment of Tetrasodium Glutamate Diacetate and Beta-Alanine Diacetic Acid as Used in Cosmetics.
Burnett CL, Bergfeld WF, Belsito DV, Cohen DE, Klaassen CD et al.
International journal of toxicology, 2025
Sodium Dehydroacetate and Dehydroacetic Acid.
Cherian P, Bergfeld WF, Belsito DV, Cohen DE, Klaassen CD et al.
International journal of toxicology, 2024
Sodium Dehydroacetate and Dehydroacetic Acid.
Cherian P, Bergfeld WF, Belsito DV, Cohen DE, Klaassen CD et al.
International journal of toxicology, 2024
Final Amended Report on the Safety Assessment of Ammonium Thioglycolate, Butyl Thioglycolate, Calcium Thioglycolate, Ethanolamine Thioglycolate, Ethyl Thioglycolate, Glyceryl Thioglycolate, Isooctyl T
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
Final Report on the Safety Assessment of Ethyl Ester of PVM/MA Copolymer and Butyl Ester of PVM/MA Copolymer
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
Final Report on the Safety Assessment of Sodium Dehydroacetate and Dehydroacetic Acid
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
Safety Assessment of Tetrasodium Glutamate Diacetate and Beta-Alanine Diacetic Acid as Used in Cosmetics
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
Sodium Dehydroacetate and Dehydroacetic Acid
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
Acetic Acid
European Commission
EU Cosmetic Ingredient Database (CosIng)
Beta-Alanine Diacetic Acid
European Commission
EU Cosmetic Ingredient Database (CosIng)
Butyl Ester of PVM/MA Copolymer
European Commission
EU Cosmetic Ingredient Database (CosIng)
Butyl Thioglycolate
European Commission
EU Cosmetic Ingredient Database (CosIng)
dehydroacetic acid
European Commission
EU Cosmetic Ingredient Database (CosIng)
Potassium Butyl Ester of PVM/MA Copolymer
European Commission
EU Cosmetic Ingredient Database (CosIng)
Acetic acid and the skin: a review of vinegar in dermatology.
Elhage KG, St Claire K, Daveluy S
International journal of dermatology, 2022
Acetic acid and the skin: a review of vinegar in dermatology.
Elhage KG, St Claire K, Daveluy S
International journal of dermatology, 2022
Acetic Acid
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
Butyl Ester of PVM/MA Copolymer
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
dehydroacetic acid
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
Potential application of novel liquid crystal nanoparticles of isostearyl glyceryl ether for transdermal delivery of 4-biphenyl acetic acid.
Fujii MY, Asakawa Y, Fukami T
International journal of pharmaceutics, 2020
Preparation of (13)C-labeled ceramide by acetic acid bacteria and its incorporation in mice.
Fukami H, Tachimoto H, Kishi M, Kaga T, Waki H et al.
Journal of lipid research, 2010
Trichloroacetic acid
Health Canada
Health Canada Cosmetic Ingredient Hotlist
Verified Feb 2026
Data: PubChem · CosIng · EWG · CIR