Chlorhexidine Digluconate
AKA “Hibiclens, Chlorhexidine gluconate, Dyna-hex, Bioscrub, Hibistat, Microderm, Periochip, Periogard”
Synthetic
Ingredient Facts
Chlorhexidine digluconate
AKA: Hibiclens, Chlorhexidine gluconate, Dyna-hex, Bioscrub, Hibistat, Microderm, Periochip, Periogard
Synthetic · Antimicrobial · EWG: 4
Synthetic
Preservative
Synthetic
Clean
A proven antimicrobial ingredient that helps keep products fresh and clean while supporting oral health formulations.
Formula
C34H54Cl2N10O14
Mol. Weight
897.80
CAS #
18472-51-0
Form
Liquid
See origin →
Functions
Antimicrobial
Keeps your product from growing bacteria, mold, or yeast. Without these, that jar of cream becomes a petri dish in about a week.
Oral Care
Preservative
Keeps your product from growing bacteria, mold, or yeast. Without these, that jar of cream becomes a petri dish in about a week.
Fights Bacteria
Traditional Use
A gluconate salt of chlorhexidine developed to increase water solubility and antimicrobial efficacy. Widely adopted from the 1970s onward in oral rinses, wound care, and antimicrobial skincare formulations.
Skin Types
●all-skin-types
Best For
General
Melanin-Rich Skin
Suitable
Pregnancy & Breastfeeding Safe
Caution
EWG
4
CIR
Safe w/Qualifications
Pregnancy
Caution
CIR Safety Findings
ewg-4
all-shades-safe
Concentration Guide
0.3%
0%0%
Reg. Limit
EU regulatory limit: 0.3%. Source: EU Cosmetics Regulation (EC) 1223/2009, Annex V (Preservatives), Entry 42.
Regulatory Agencies
Final Report on the Safety Assessment of Chlorhexidine/Chlorhexidine Diacetate/Chlorhexidine Dihydrochloride/Chlorhexidine Digluconate
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
Note Regarding the Safety Assessment of Chlorhexidine, Chlorhexidine Diacetate, Chlorhexidine Digluconate, and Chlorhexidine Dihydrochloride
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
Verified Feb 2026
Data: PubChem · CosIng · EWG · CIR