Cholecalciferol
AKA “Vitamin D3, Colecalciferol, Calciol, Oleovitamin D3, Ricketon, Deparal, Arachitol, Delsterol”
Synthetic
Ingredient Facts
Cholecalciferol
AKA: Vitamin D3, Colecalciferol, Calciol, Oleovitamin D3, Ricketon, Deparal, Arachitol, Delsterol
Synthetic · Oral-Care · EWG: 4
Synthetic
Skin Conditioner
Synthetic
Clean
Vitamin D3 helps condition and strengthen hair and teeth by supporting natural moisture retention and resilience.
Solubility Insoluble (NTP, 1992)
Formula
C27H44O
Mol. Weight
384.60
CAS #
67-97-0
Form
Oil
State
Vitamin d3 appears as fine colorless crystals. Water insoluble. (NTP, 1992)
See origin →
Functions
Oral-Care
Conditioning
A catch-all term for ingredients that improve how skin looks and feels — softer, smoother, more supple. The workhorse behind most moisturizers.
Oral Care
Skin Conditioning Miscellaneous
Improves skin feel
Supports dental health
Traditional Use
Vitamin D was isolated in 1932. D3 (cholecalciferol) was synthesized and began appearing in skincare products in the 1980s-1990s after research demonstrated its role in skin cell regulation and immune function.
Skin Types
●all-skin-types
Best For
General
Melanin-Rich Skin
Suitable
Pregnancy & Breastfeeding Safe
Yes
Investigating transdermal delivery of vitamin D3.
Alsaqr A, Rasoully M, Musteata FM
AAPS PharmSciTech, 2015
Targeting LINC00707 by vitamin D3 attenuates nitrogen mustard-caused dermal toxicity through inhibiting ferroptosis.
Dong X, He Y, Hu X, Wu J, Ye F et al.
Redox biology, 2025
Cholecalciferol
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
Cholecalciferol, 1 Alpha,25 Dihydroxy
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
Vitamin D3
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
Cholecalciferol
Health Canada
Health Canada Cosmetic Ingredient Hotlist
Effects of 1 alpha,25-dihydroxy-vitamin D3 and calcipotriol on organotypic cultures of outer root sheath cells: a potential model to evaluate antipsor
Limat A, Hunziker T, Braathen LR
Archives of dermatological research, 1993
Verified Feb 2026
Data: PubChem · CosIng · EWG · CIR