Cholecalciferol, 1 Alpha,25 Dihydroxy
AKA “Calcitriol, 25-dihydroxycholecalciferol, Active vitamin D3”
Vitamin D3
Ingredient Facts
Cholecalciferol, 1 alpha,25 dihydroxy
AKA: Calcitriol, 25-dihydroxycholecalciferol, Active vitamin D3
Vitamin D3 · Soothing · EWG: 1
Synthetic
Soothing
Skin Conditioner
Vitamin D3
Clean
Safety Ratings: EWG: 1/10 (Low Hazard)
Formula
C27H44O3
Mol. Weight
416.64
CAS #
32222-06-3
Form
Powder
See origin →
Functions
Skin Conditioning
A catch-all term for ingredients that improve how skin looks and feels — softer, smoother, more supple. The workhorse behind most moisturizers.
Soothing
Calms redness, irritation, and inflammation. Your skin's chill pill — great for sensitive, reactive, or post-procedure skin.
Antioxidant
Protects skin from free radical damage caused by UV, pollution, and stress
Anti-Inflammatory
Antimicrobial
Provides scent
Traditional Use
The active metabolite of vitamin D was first identified in 1937. Its use in skincare developed in the 2000s when research demonstrated its role in skin barrier function, immune regulation, and anti-inflammatory benefits.
Skin Types
●all-skin-types, gentle
Best For
General
Melanin-Rich Skin
Suitable
Pregnancy & Breastfeeding Safe
Caution
Verified Feb 2026
Data: PubChem · CosIng · EWG · CIR