Cyclohexasiloxane
AKA “Cyclohexasiloxane, Cyclomethicone 6, XIAMETER PMX-0246, 12-Dodecamethylcyclohexasiloxane”
Synthetic
Ingredient Facts
Cyclohexasiloxane
AKA: Cyclomethicone 6, XIAMETER PMX-0246, 12-Dodecamethylcyclohexasiloxane
Synthetic · Emollient · EWG: 4
Synthetic
Emollient
Solvent
Skin Conditioner
Hair Care
Silicone
Synthetic
Clean
A lightweight conditioning agent that helps smooth hair and skin while improving softness and shine. Leaves a silky feel without heaviness.
Formula
C12H36O6Si6
Mol. Weight
444.92
CAS #
540-97-6
Form
Liquid
State
Liquid
See origin →
Functions
Hair Conditioning
A catch-all term for ingredients that improve how skin looks and feels — softer, smoother, more supple. The workhorse behind most moisturizers.
Emollient
Fills in the tiny cracks between skin cells to make everything feel smooth and soft. The "silky finish" ingredient.
Solvent
Dissolves other ingredients so they distribute evenly in the formula. Often the invisible "base" everything else is mixed into.
Locks In Moisture
Traditional Use
A cyclic silicone developed in the 1950s-1960s during silicone polymer research. Used in cosmetics as a non-greasy emollient and spreading agent, offering an alternative to traditional oil-based ingredients.
Skin Types
●all-skin-types
Best For
General
Melanin-Rich Skin
Suitable
Pregnancy & Breastfeeding Safe
Yes
Safety assessment of Cyclomethicone, Cyclotetrasiloxane, Cyclopentasiloxane, Cyclohexasiloxane and Cycloheptasiloxane
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
Cyclohexasiloxane
European Commission
EU Cosmetic Ingredient Database (CosIng)
Cyclohexasiloxane
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
Safety assessment of cyclomethicone, cyclotetrasiloxane, cyclopentasiloxane, cyclohexasiloxane, and cycloheptasiloxane.
Johnson W Jr, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD et al.
International journal of toxicology, 2011
Safety assessment of cyclomethicone, cyclotetrasiloxane, cyclopentasiloxane, cyclohexasiloxane, and cycloheptasiloxane.
Johnson W Jr, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD et al.
International journal of toxicology, 2011
Safety assessment of cyclomethicone, cyclotetrasiloxane, cyclopentasiloxane, cyclohexasiloxane, and cycloheptasiloxane.
Johnson W Jr, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD et al.
International journal of toxicology, 2011
Risk assessment of cyclohexasiloxane D6 in cosmetic products.
Ko Y, Lim D, Choi H, Choi S, Choi S et al.
Toxicological research, 2024
Verified Feb 2026
Data: PubChem · CosIng · EWG · CIR