Glycyrrhetinic Acid
AKA “enoxolone, Glycyrrhetic acid, Uralenic acid, 18-beta-Glycyrrhetinic acid, Enoxolona, 3beta-Hydroxy-11-oxoolean-12-en-30-oic acid, Enoxolonum, Rhetinic Acid”
Synthetic
Ingredient Facts
Glycyrrhetinic acid
AKA: Enoxolone, Glycyrrhetic acid, Uralenic acid, 18-beta-Glycyrrhetinic acid, Enoxolona, 3beta-Hydroxy-11-oxoolean-12-en-30-oic acid, Enoxolonum
Synthetic · Antioxidant · EWG: 4
Synthetic
Antioxidant
Soothing
Skin Conditioner
Synthetic
Clean
A soothing botanical extract derived from licorice root that calms irritation and supports skin's natural balance, leaving complexion feeling comfortable and conditioned.
Formula
C30H46O4
Mol. Weight
470.70
CAS #
471-53-4
Form
Liquid
State
Solid
See origin →
Functions
Skin Conditioning
A catch-all term for ingredients that improve how skin looks and feels — softer, smoother, more supple. The workhorse behind most moisturizers.
Soothing
Calms redness, irritation, and inflammation. Your skin's chill pill — great for sensitive, reactive, or post-procedure skin.
Antioxidant
Fights free radicals — the unstable molecules from UV, pollution, and stress that break down collagen and cause premature aging.
Locks in moisture
Traditional Use
The active triterpene compound extracted from licorice root, isolated and studied extensively in the 1970s-1980s. Used in skincare for anti-inflammatory and skin-soothing properties, building on licorice's traditional use in Asian medicine.
Skin Types
●all-skin-types
Best For
Redness
Melanin-Rich Skin
Suitable
Pregnancy & Breastfeeding Safe
Caution
Final Report on the Safety Assessment of Glycyrrhetinic Acid, Potassium Glycyrrhetinate, Disodium Succinoyl Glycyrrhetinate, Glyceryl Glycyrrhetinate, Stearyl Glycyrrhetinate, Glycyrrhizic Acid, Ammon
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
Allantoin Glycyrrhetinic Acid
European Commission
EU Cosmetic Ingredient Database (CosIng)
Glycyrrhetinic Acid
European Commission
EU Cosmetic Ingredient Database (CosIng)
Final report on the safety assessment of Glycyrrhetinic Acid, Potassium Glycyrrhetinate, Disodium Succinoyl Glycyrrhetinate, Glyceryl Glycyrrhetinate,
Cosmetic Ingredient Review Expert Panel
International journal of toxicology, 2007
Final report on the safety assessment of Glycyrrhetinic Acid, Potassium Glycyrrhetinate, Disodium Succinoyl Glycyrrhetinate, Glyceryl Glycyrrhetinate,
Cosmetic Ingredient Review Expert Panel
International journal of toxicology, 2007
Final report on the safety assessment of Glycyrrhetinic Acid, Potassium Glycyrrhetinate, Disodium Succinoyl Glycyrrhetinate, Glyceryl Glycyrrhetinate,
Cosmetic Ingredient Review Expert Panel
International journal of toxicology, 2007
Final report on the safety assessment of Glycyrrhetinic Acid, Potassium Glycyrrhetinate, Disodium Succinoyl Glycyrrhetinate, Glyceryl Glycyrrhetinate,
Cosmetic Ingredient Review Expert Panel
International journal of toxicology, 2007
Final report on the safety assessment of Glycyrrhetinic Acid, Potassium Glycyrrhetinate, Disodium Succinoyl Glycyrrhetinate, Glyceryl Glycyrrhetinate,
Cosmetic Ingredient Review Expert Panel
International journal of toxicology, 2007
Final report on the safety assessment of Glycyrrhetinic Acid, Potassium Glycyrrhetinate, Disodium Succinoyl Glycyrrhetinate, Glyceryl Glycyrrhetinate,
Cosmetic Ingredient Review Expert Panel
International journal of toxicology, 2007
Final report on the safety assessment of Glycyrrhetinic Acid, Potassium Glycyrrhetinate, Disodium Succinoyl Glycyrrhetinate, Glyceryl Glycyrrhetinate,
Cosmetic Ingredient Review Expert Panel
International journal of toxicology, 2007
Final report on the safety assessment of Glycyrrhetinic Acid, Potassium Glycyrrhetinate, Disodium Succinoyl Glycyrrhetinate, Glyceryl Glycyrrhetinate,
Cosmetic Ingredient Review Expert Panel
International journal of toxicology, 2007
Allantoin Glycyrrhetinic Acid
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
Glycyrrhetinic Acid
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
Verified Feb 2026
Data: PubChem · CosIng · EWG · CIR