Histidine
AKA “L-histidine, glyoxaline-5-alanine, L-(-)-Histidine, histidina, Istidina, HISTIDINE, (2S)-2-amino-3-(1H-imidazol-4-yl)propanoic acid, L-Histidin”
Synthetic
Ingredient Facts
Histidine
AKA: L-histidine, Glyoxaline-5-alanine, L-(-)-Histidine, Histidina, Istidina, (2S)-2-amino-3-(1H-imidazol-4-yl)propanoic acid, L-Histidin
Synthetic · Humectant · EWG: 4
Synthetic
Humectant
Skin Conditioner
Synthetic
Clean
Histidine is an amino acid that helps your hair and skin retain moisture while reducing frizz and static. It conditions and smooths the hair shaft for a sleeker appearance.
Solubility 45600
Formula
C6H9N3O2
Mol. Weight
155.15
CAS #
71-00-1
Form
Liquid
State
Solid; [Merck Index] Powder; [Sigma-Aldrich MSDS]
See origin →
Functions
Antistatic
Humectant
A moisture magnet. Pulls water from the air and deeper skin layers up to the surface to keep skin plump and hydrated.
Skin Conditioning
A catch-all term for ingredients that improve how skin looks and feels — softer, smoother, more supple. The workhorse behind most moisturizers.
Locks In Moisture
Traditional Use
An amino acid discovered in 1896. Became recognized in the early 20th century for its role in skin barrier function and moisture retention, incorporated into skincare formulations in the 1960s-1970s.
Skin Types
●all-skin-types
Best For
General
Melanin-Rich Skin
Suitable
Pregnancy & Breastfeeding Safe
Yes
Histidine Metabolism and Function.
Brosnan ME, Brosnan JT
The Journal of nutrition, 2020
Histidine Metabolism and Function.
Brosnan ME, Brosnan JT
The Journal of nutrition, 2020
Histidine Metabolism and Function.
Brosnan ME, Brosnan JT
The Journal of nutrition, 2020
Histidine Metabolism and Function.
Brosnan ME, Brosnan JT
The Journal of nutrition, 2020
Histidine Metabolism and Function.
Brosnan ME, Brosnan JT
The Journal of nutrition, 2020
Histidine Metabolism and Function.
Brosnan ME, Brosnan JT
The Journal of nutrition, 2020
Acetyl Histidine
European Commission
EU Cosmetic Ingredient Database (CosIng)
Histidine
European Commission
EU Cosmetic Ingredient Database (CosIng)
Histidine HCl
European Commission
EU Cosmetic Ingredient Database (CosIng)
Safety and efficacy of l-histidine monohydrochloride monohydrate produced using Corynebacterium glutamicum KCCM 80179 for all animal species.
EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP), Bampidis V, Azimonti G, de Lourdes Bastos M, Christensen H et al.
EFSA journal. European Food Safety Authority, 2019
Histidine
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
Histidine HCl
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
Verified Feb 2026
Data: PubChem · CosIng · EWG · CIR