Human Placental Enzymes
AKA “placental enzymes, placenta extract
Synthetic
Ingredient Facts
Human placental enzymes
AKA: Placenta extract
Synthetic · Hair Conditioning · EWG: 4
Synthetic
Skin Conditioner
Hair Care
Synthetic
Clean
Human Placental Enzymes are the enzymes derived from human placentas obtained from normal afterbirth Science: Functions: Hair Conditioning, Skin Conditioning Safety Ratings: CIR: Safe as used EU Restriction: II/416
CAS #
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Form
Powder
See origin →
Functions
Hair Conditioning
A catch-all term for ingredients that improve how skin looks and feels — softer, smoother, more supple. The workhorse behind most moisturizers.
Skin Conditioning
A catch-all term for ingredients that improve how skin looks and feels — softer, smoother, more supple. The workhorse behind most moisturizers.
Locks in moisture
Traditional Use
Placental enzymes became a cosmetic ingredient in the early 20th century, particularly in Japanese and European skincare, based on the belief that placental proteins and enzymes could promote cellular turnover and collagen production. Their use in cosmetics remains controversial due to ethical sourcing concerns.
Skin Types
all-skin-types
Best For
Uneven Texture
Melanin-Rich Skin
Suitable
Pregnancy & Breastfeeding Safe
Caution
EWG
4
CIR
Insufficient
Pregnancy
Caution
CIR Safety Findings
Not a Sensitizer
medical-approval
all-shades-safe
Regulatory Status
USAunder review
EUpermitted
JAPANpermitted
CANADApermitted
Final Report on the Safety Assessment of Human Placental Protein, Hydrolyzed Human Placental Protein, Human Placental Enzymes, Human Placental Lipids, Human Umbilical Extract, Placental Protein, Hydro
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
Glycine Max (Soybean) Phytoplacenta Extract
European Commission
EU Cosmetic Ingredient Database (CosIng)
Glycine Soja (Soybean) Phytoplacenta Extract
European Commission
EU Cosmetic Ingredient Database (CosIng)
Placental Enzymes
European Commission
EU Cosmetic Ingredient Database (CosIng)
Glycine Soja (Soybean) Phytoplacenta Extract
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
Final report on the safety assessment of human placental protein, hydrolyzed human placental protein, human placental enzymes, human placental lipids,
Nair B, Elmore AR, Cosmetic Ingredient Review Expert panel
International journal of toxicology, 2002
Final report on the safety assessment of human placental protein, hydrolyzed human placental protein, human placental enzymes, human placental lipids,
Nair B, Elmore AR, Cosmetic Ingredient Review Expert panel
International journal of toxicology, 2002
Final report on the safety assessment of human placental protein, hydrolyzed human placental protein, human placental enzymes, human placental lipids,
Nair B, Elmore AR, Cosmetic Ingredient Review Expert panel
International journal of toxicology, 2002
Final report on the safety assessment of human placental protein, hydrolyzed human placental protein, human placental enzymes, human placental lipids,
Nair B, Elmore AR, Cosmetic Ingredient Review Expert panel
International journal of toxicology, 2002
Final report on the safety assessment of human placental protein, hydrolyzed human placental protein, human placental enzymes, human placental lipids,
Nair B, Elmore AR, Cosmetic Ingredient Review Expert panel
International journal of toxicology, 2002
Final report on the safety assessment of human placental protein, hydrolyzed human placental protein, human placental enzymes, human placental lipids,
Nair B, Elmore AR, Cosmetic Ingredient Review Expert panel
International journal of toxicology, 2002
Final report on the safety assessment of human placental protein, hydrolyzed human placental protein, human placental enzymes, human placental lipids,
Nair B, Elmore AR, Cosmetic Ingredient Review Expert panel
International journal of toxicology, 2002
Final report on the safety assessment of human placental protein, hydrolyzed human placental protein, human placental enzymes, human placental lipids,
Nair B, Elmore AR, Cosmetic Ingredient Review Expert panel
International journal of toxicology, 2002
Final report on the safety assessment of human placental protein, hydrolyzed human placental protein, human placental enzymes, human placental lipids,
Nair B, Elmore AR, Cosmetic Ingredient Review Expert panel
International journal of toxicology, 2002
Final report on the safety assessment of human placental protein, hydrolyzed human placental protein, human placental enzymes, human placental lipids,
Nair B, Elmore AR, Cosmetic Ingredient Review Expert panel
International journal of toxicology, 2002
Verified Feb 2026
Data: CosIng · EWG · CIR