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Lysolecithin
AKA “Lysocithin, RefChem:800216, 1-Palmitoylphosphatidylcholine, DL-gamma-Palmitoyl-alpha-lysolecithin, 1-Palmitoyl-rac-glycero-3-phosphocholine, Synthetic, PC(16:0/0:0)[rac]”
Fatty Acid
Ingredient Facts
Lysolecithin
AKA: Lysocithin, RefChem:800216, 1-Palmitoylphosphatidylcholine, DL-gamma-Palmitoyl-alpha-lysolecithin, 1-Palmitoyl-rac-glycero-3-phosphocholine, Synthetic, PC(16:0/0:0)[rac]
Fatty Acid · Emollient · EWG: 3
Synthetic
Emollient
Cleanser
Emulsifier
Skin Conditioner
Plant Oil
Fatty Acid
Clean
A natural emulsifier that blends water and oil-based ingredients together, helping create smooth, lightweight formulas that absorb easily into skin.
Formula
C24H50NO7P
Mol. Weight
495.60
CAS #
85711-58-6
Form
Liquid
See origin →
Functions
Emulsifying
Forces oil and water to stay mixed instead of separating into layers. The unsung hero holding your lotion together.
Skin Conditioning
A catch-all term for ingredients that improve how skin looks and feels — softer, smoother, more supple. The workhorse behind most moisturizers.
Emollient
Fills in the tiny cracks between skin cells to make everything feel smooth and soft. The "silky finish" ingredient.
Emulsifier
Mixes Oil & Water
Traditional Use
Lecithin was first isolated from egg yolks in the 1800s; lysophosphatidylcholine (lysolecithin) is a derivative developed in the 20th century as a modern emulsifier and skin conditioning agent with no traditional use history.
Skin Types
●all-skin-types
Best For
General
Melanin-Rich Skin
Suitable
Pregnancy & Breastfeeding Safe
Yes
EWG
3
CIR
Safe
Pregnancy
Yes
CIR Safety Findings
Not a Sensitizer
medical-approval
all-shades-safe
Regulatory Status
USA✔ permitted
EU⚠ restricted
JAPAN⚠ restricted
CANADA⚠ restricted
Safety Assessment of Synthetic Fluorphlogopite as Used in Cosmetics.
Becker LC, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD et al.
International journal of toxicology, 2015
→
Amended Safety Assessment of Synthetically Manufactured Amorphous Silica and Hydrated Silica as Used in Cosmetics
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
Extended Re-review Summary: Safety Assessment of Fossil and Synthetic Waxes as Used in Cosmetics
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
Final Report on the Safety Assessment of Fossil and Synthetic Waxes
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
Safety Assessment of Synthetic Fluorphlogopite as Used in Cosmetics
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
Hydrogenated Lysolecithin
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Lysolecithin
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Synthetic Beeswax
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Synthetic Fluorphlogopite
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Synthetic Jojoba Oil
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Synthetic Wax
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Lysolecithin
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Synthetic Beeswax
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Synthetic Fluorphlogopite
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Synthetic Jojoba Oil
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Synthetic Wax
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Curarizants, synthetic
Health Canada
Health Canada Cosmetic Ingredient Hotlist
→
Narcotics, natural and synthetic
Health Canada
Health Canada Cosmetic Ingredient Hotlist
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Natural soap is clinically effective and less toxic and more biodegradable in aquatic organisms and human skin cells than synthetic detergents.
Kanyama T, Masunaga A, Kawahara T, Morita H, Akita S
PloS one, 2025
→
Natural soap is clinically effective and less toxic and more biodegradable in aquatic organisms and human skin cells than synthetic detergents.
Kanyama T, Masunaga A, Kawahara T, Morita H, Akita S
PloS one, 2025
→
Dermal exposure to synthetic musks: Human health risk assessment, mechanism, and control strategy.
Li X, He W, Zhao Y, Chen B, Zhu Z et al.
Ecotoxicology and environmental safety, 2022
→
Establishing biosynthetic pathway for the production of p-hydroxyacetophenone and its glucoside in Escherichia coli.
Lu L, Wang X, Zhou L, Liu Q, Zhang G et al.
Metabolic engineering, 2023
→
Jojoba Oil Soft Colloidal Nanocarrier of a Synthetic Retinoid: Preparation, Characterization and Clinical Efficacy in Psoriatic Patients.
Nasr M, Abdel-Hamid S, Moftah NH, Fadel M, Alyoussef AA
Current drug delivery, 2017
→
Do Synthetic Fragrances in Personal Care and Household Pr...
Gandhi Rádis-Baptista
Journal of xenobiotics, 2023
→
Usage of Synthetic Peptides in Cosmetics for Sensitive Skin.
Resende DISP, Ferreira MS, Sousa-Lobo JM, Sousa E, Almeida IF
Pharmaceuticals (Basel, Switzerland), 2021
→
The Neolignan Honokiol and Its Synthetic Derivative Honokiol Hexafluoro Reduce Neuroinflammation and Cellular Senescence in Microglia Cells.
Sasia C, Borgonetti V, Mancini C, Lori G, Arbiser JL et al.
Cells, 2024
→
Semisynthetic Derivative of Artemisia annua-Loaded Transdermal Bioadhesive for the Treatment of Uncomplicated Malaria Caused by Plasmodium falciparum
Volpe Zanutto F, McAlister E, Marucci Pereira Tangerina M, Fonseca-Santos B, Costa Salles TH et al.
Journal of pharmaceutical sciences, 2019
→
Bioprospecting photosynthetic microorganisms for the remo...
Birgitta Narindri Rara Winayu, Feng-Jen Chu, Christoper Caesar Yudho Sutopo, Hsin Chu
World journal of microbiology & biotechnology, 2024
→
Verified Feb 2026
Data: PubChem · CosIng · EWG · CIR