Methoxyisopropanol
AKA “1-Methoxy-2-propanol, 1-Methoxypropan-2-ol, Closol, PGME, 2-Propanol, 1-Methoxy-2-hydroxypropane, Dowtherm 209, Propylene glycol monomethyl ether
Synthetic
Ingredient Facts
Methoxyisopropanol
AKA: 1-Methoxy-2-propanol, 1-Methoxypropan-2-ol, Closol, PGME, 2-Propanol, 1-Methoxy-2-hydroxypropane, Dowtherm 209, Propylene glycol monomethyl ether
Synthetic · Perfuming · EWG: 4
Synthetic
Fragrance
Solvent
Synthetic
Clean
A synthetic ingredient that helps fragrances blend smoothly into products and keeps formulas stable and effective.
Solubility greater than or equal to 100 mg/mL at 66 °F (NTP, 1992)
Formula
C4H10O2
Mol. Weight
90.12
CAS #
107-98-2
Form
Liquid
State
1-methoxy-2-propanol appears as a colorless liquid. Flash point near 89 °F. Less dense than water. Contact irritates skin, eyes and mucous membranes. Prolonged exposure to vapors may cause coughing, s
See origin →
Functions
Perfuming
Added for scent. Can be natural or synthetic. Common irritant and allergen — one of the top reasons people react to products.
Solvent
Dissolves other ingredients so they distribute evenly in the formula. Often the invisible "base" everything else is mixed into.
Adds Fragrance
Dissolves Ingredients
Adds pleasant scent
Dissolves other ingredients
Traditional Use
A synthetic solvent developed in the 20th century for industrial and cosmetic use. Functions in cosmetics to improve product spreadability and evaporation characteristics.
Skin Types
all-skin-types
Best For
General
Melanin-Rich Skin
Suitable
Pregnancy & Breastfeeding Safe
Caution
EWG
4
CIR
Insufficient
Pregnancy
Caution
CIR Safety Findings
Not a Sensitizer
medical-approval
all-shades-safe
Regulatory Status
USAunder review
EUrestricted
JAPANrestricted
CANADArestricted
Final Report on the Safety Assessment of Methoxyisopropanol and Methoxyisopropyl Acetate as Used in Cosmetics
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
Methoxyisopropanol
European Commission
EU Cosmetic Ingredient Database (CosIng)
Final report on the safety assessment of methoxyisopropanol and methoxyisopropyl acetate as used in cosmetics.
Cosmetic Ingredient Review Expert Panel
International journal of toxicology, 2008
2-Methyl-1-Phenyl-2-Propanol
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
Methoxyisopropanol
Health Canada
Health Canada Cosmetic Ingredient Hotlist
Urinary excretion of propylene glycol butyl ether (PGBE) and propylene glycol methyl ether (PGME) in healthy human participants and workers.
Hopf NB, Kaspar S, Berthet A, Hechon J, Pache J et al.
International journal of hygiene and environmental health, 2026
Verified Feb 2026
Data: PubChem · CosIng · EWG · CIR