Methoxyisopropyl Acetate
AKA “Propylene glycol methyl ether acetate, PGMEA cpd, RefChem:433493, 1-Methoxy-2-propyl acetate, 1-methoxypropan-2-yl acetate, Propylene glycol monomethyl ether acetate, 2-Acetoxy-1-methoxypropane, 1-Methoxy-2-acetoxypropane
Synthetic
Ingredient Facts
Methoxyisopropyl acetate
AKA: Propylene glycol methyl ether acetate, PGMEA cpd, RefChem:433493, 1-Methoxy-2-propyl acetate, 1-methoxypropan-2-yl acetate, Propylene glycol monomethyl ether acetate, 2-Acetoxy-1-methoxypropane, 1-Methoxy-2-acetoxypropane
Synthetic · Emollient · EWG: 4
Synthetic
Emollient
Solvent
Skin Conditioner
Synthetic
Clean
A lightweight solvent that helps blend and dissolve other ingredients, ensuring a smooth, even product texture that absorbs cleanly into skin.
Solubility In water, 1.98X10+5 mg/L at 25 °C
Formula
C6H12O3
Mol. Weight
132.16
CAS #
108-65-6
Form
Liquid
State
Propylene glycol methyl ether acetate is a colorless liquid with a sweet ether-like odor. (USCG, 1999)
See origin →
Functions
Solvent
Dissolves other ingredients so they distribute evenly in the formula. Often the invisible "base" everything else is mixed into.
Viscosity Controlling
Emollient
Fills in the tiny cracks between skin cells to make everything feel smooth and soft. The "silky finish" ingredient.
Dissolves Ingredients
Dissolves other ingredients
Traditional Use
A modern synthetic solvent created for cosmetic formulations. Used in skincare and color cosmetics to improve texture, evaporation, and product performance.
Skin Types
all-skin-types
Best For
General
Melanin-Rich Skin
Suitable
Pregnancy & Breastfeeding Safe
Caution
EWG
4
CIR
Insufficient
Pregnancy
Caution
CIR Safety Findings
Not a Sensitizer
medical-approval
all-shades-safe
Regulatory Status
USAunder review
EUrestricted
JAPANrestricted
CANADArestricted
Verified Feb 2026
Data: PubChem · CosIng · EWG · CIR