Methyl Glycyrrhizate
AKA “GAMME, Glycyrrhizic acid methyl ester, RefChem:144015, DTXCID401506590, UNII-A4TET7070S, (2S, 14bS)-11-methoxycarbonyl-4, 14b-heptamethyl-14-oxo-2”
Synthetic
Ingredient Facts
Methyl glycyrrhizate
AKA: GAMME, Glycyrrhizic acid methyl ester, RefChem:144015, DTXCID401506590, UNII-A4TET7070S, (2S, 14bS)-11-methoxycarbonyl-4, 14b-heptamethyl-14-oxo-2
Synthetic · Antioxidant · EWG: 4
Synthetic
Antioxidant
Soothing
Skin Conditioner
Synthetic
Clean
Derived from licorice root, this natural-origin fragrance ingredient adds a subtle, warm scent to the formula while complementing the product's skincare benefits.
Formula
C43H62O16-2
Mol. Weight
834.90
CAS #
104191-95-9
Form
Powder
See origin →
Functions
Soothing
Calms redness, irritation, and inflammation. Your skin's chill pill — great for sensitive, reactive, or post-procedure skin.
Skin Conditioning
A catch-all term for ingredients that improve how skin looks and feels — softer, smoother, more supple. The workhorse behind most moisturizers.
Antioxidant
Fights free radicals — the unstable molecules from UV, pollution, and stress that break down collagen and cause premature aging.
Brightens uneven skin tone
Evens pigmentation
Quells irritation
Traditional Use
Derived from licorice (Glycyrrhiza glabra), which has been used in Traditional Chinese Medicine and Ayurveda for over 2,000 years for skin soothing and anti-inflammatory benefits. The methylated form was developed to improve stability in modern cosmetic formulations.
Skin Types
●all-skin-types
Best For
Irritation
Melanin-Rich Skin
Suitable
Pregnancy & Breastfeeding Safe
Yes
Verified Feb 2026
Data: PubChem · CosIng · EWG · CIR