Morpholine
AKA “1-Oxa-4-azacyclohexane, Diethylene oximide, Tetrahydro-1, 4-oxazine, Diethylenimide oxide, Diethyleneimide oxide, Diethylene imidoxide, Drewamine”
Synthetic
Ingredient Facts
Morpholine
AKA: 1-Oxa-4-azacyclohexane, Diethylene oximide, Tetrahydro-1, 4-oxazine, Diethylenimide oxide, Diethyleneimide oxide, Diethylene imidoxide, Drewamine
Synthetic · Buffering · EWG: 4
Synthetic
Synthetic
Clean
Morpholine helps balance the pH of our formula, keeping it gentle and comfortable on skin while maintaining product stability.
Solubility Soluble (NTP, 1992)
Formula
C4H9NO
Mol. Weight
87.12
CAS #
110-91-8
Form
Liquid
State
Morpholine appears as a colorless liquid with a fishlike odor. Flash point 100 °F. Corrosive to tissue. Less dense than water and soluble in water. Vapors heavier than air. Used to make other chemical
See origin →
Functions
Buffering
pH Adjusting
Anti-Inflammatory
Antimicrobial
Fights Acne
Maintains optimal pH
Traditional Use
Developed in the early 20th century as an organic compound in industrial chemistry. Adopted in cosmetics as a pH adjuster and buffering agent, particularly in formulations requiring stable acidity control.
Skin Types
●all-skin-types
Best For
General
Melanin-Rich Skin
Suitable
Pregnancy & Breastfeeding Safe
Caution
Final Report on the Safety Assessment of Hydroxybenzomorpholine
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
Final Report on the Safety Assessment of Isostearamidopropyl Morpholine Lactate
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
Final Report on the Safety Assessment of Morpholine
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
Hydroxybenzomorpholine
European Commission
EU Cosmetic Ingredient Database (CosIng)
Isostearamidopropyl Morpholine Lactate
European Commission
EU Cosmetic Ingredient Database (CosIng)
Hydroxybenzomorpholine
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
Isostearamidopropyl Morpholine Lactate
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
Morpholine
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
Isostearamidopropyl Morpholine Lactate.
Fiume MM
International journal of toxicology, 2017
Isostearamidopropyl Morpholine Lactate.
Fiume MM
International journal of toxicology, 2017
Morpholine and its salts
Health Canada
Health Canada Cosmetic Ingredient Hotlist
Verified Feb 2026
Data: PubChem · CosIng · EWG · CIR