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PROPANE-1
AKA “bronopol, 52-51-7, 2-Bromo-2-nitro-1, 3-propanediol, 2-Bromo-2-nitropropane-1, 3-diol, Bronosol, Bronocot, Bronotak, Bronidiol, Bronopolu, Lexgard bronopol”
Preservative
Ingredient Facts
PROPANE-1
AKA: Bronopol, 52-51-7, 2-Bromo-2-nitro-1, 3-propanediol, 2-Bromo-2-nitropropane-1, 3-diol, Bronosol, Bronocot, Bronotak, Bronidiol, Bronopolu, Lexgard bronopol
Preservative · Preservative · EWG: 7
Synthetic
Preservative
Not Clean
1,3-Propanediol, 2-bromo-2-nitro-
Solubility greater than or equal to 100 mg/mL at 63 °F (NTP, 1992)
Mol. Weight
199.99
CAS #
52-51-7
State
2-bromo-2-nitropropane-1,3-diol appears as white crystals. Ignite easily and burn readily. May detonate under strong shock. Decomposes when heated, evolving toxic gases. Toxic by skin absorption, inha
See origin →
Functions
Preservative
Keeps your product from growing bacteria, mold, or yeast. Without these, that jar of cream becomes a petri dish in about a week.
EWG
7
CIR
—
Pregnancy
—
Regulatory Status
EU✔ permitted
JAPAN✔ permitted
CANADA✔ permitted
Regulatory Agencies
Addendum to the Final Report on the Safety Assessment of 2-Bromo-2-Nitropropane-1,3-Diol (JEPT 4(4) 47-61 1980)
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
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Final Report of the Safety Assessment for 2-Bromo-2-Nitropropane-1,3-Diol
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
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Revised Tentative Report: Amended Safety Assessment of 2-Bromo-2-Nitropropane-1,3-Diol as Used in Cosmetics
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
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2-Bromo-2-Nitropropane-1,3-Diol
European Commission
EU Cosmetic Ingredient Database (CosIng)
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2-Bromo-2-Nitropropane-1,3-Diol
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
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PROPANE-1
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
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The Additive Influence of Propane-1,2-Diol on SDS Micellar Structure and Properties.
Gudelj M, Šurina P, Jurko L, Prkić A, Bošković P
Molecules (Basel, Switzerland), 2021
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2-Bromo-2-nitropropane-1,3-diol
Health Canada
Health Canada Cosmetic Ingredient Hotlist
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Progress in 1,3-propanediol biosynthesis.
Li B, Gao W, Pan Y, Yao Y, Liu G
Frontiers in bioengineering and biotechnology, 2024
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Effects of 1,3-propanediol associated, or not, with butylene glycol and/or glycerol on skin hydration and skin barrier function.
Pinto JR, Monteiro E Silva SA, Leonardi GR
International journal of cosmetic science, 2024
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Kitty Litter Dermatitis from-Bromo-2-Nitropropane-1,3-Diol.
Sullenbarger JW, Hensley B, Travers JB
Skinmed, 2017
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Verified Jun 2026
Data: PubChem · CosIng · EWG