Sodium Thioglycolate
AKA “Sodium mercaptoacetate, Mercaptoacetic acid sodium salt, Sodium thioglycollate, Thioglycolate sodium, Mercaptoacetic acid, sodium salt, sodium sulfanylacetate, Sodium 2-mercatoethanoate
Synthetic
Ingredient Facts
Sodium thioglycolate
AKA: Sodium mercaptoacetate, Mercaptoacetic acid sodium salt, Sodium thioglycollate, Thioglycolate sodium, Mercaptoacetic acid, Sodium salt, Sodium sulfanylacetate, Sodium 2-mercatoethanoate
Synthetic · Antioxidant · EWG: 4
Synthetic
Antioxidant
Medicated Active
Synthetic
Clean
A chemical that helps break down and reshape hair structure, commonly used in hair relaxers and permanent wave treatments to create straighter or curled styles.
Solubility Very soluble (NTP, 1992)
Formula
C2H3NaO2S
Mol. Weight
114.10
CAS #
367-51-1
Form
Powder
State
Thioglycolic acid, sodium salt is a white powder with a slight odor. Used in cold-waving of hair and as a dipilatory.
See origin →
Functions
Antioxidant
Fights free radicals — the unstable molecules from UV, pollution, and stress that break down collagen and cause premature aging.
Depilatory
Hair Waving Or Straightening
Reducing
Neutralizes Free Radicals
Traditional Use
Developed in the mid-20th century as a chemical reducing agent for hair relaxation and permanent wave treatments. It replaced older, more caustic methods of breaking down hair protein bonds and became the standard ingredient in chemical hair straightening products.
Skin Types
all-skin-types
Best For
General
Melanin-Rich Skin
Suitable
Pregnancy & Breastfeeding Safe
Caution
EWG
4
CIR
Safe w/Qualifications
Pregnancy
Caution
CIR Safety Findings
Not a Sensitizer
medical-approval
all-shades-safe
Regulatory Status
USApermitted
EUpermitted
JAPANpermitted
CANADApermitted
Verified Feb 2026
Data: PubChem · CosIng · EWG · CIR