Mannitol
AKA “D-mannitol, Mannite, Osmitrol, Manna sugar, Cordycepic acid, Diosmol, Resectisol, Mannidex
Synthetic
Ingredient Facts
Mannitol
AKA: D-mannitol, Mannite, Osmitrol, Manna sugar, Cordycepic acid, Diosmol, Resectisol, Mannidex
Synthetic · Humectant · EWG: 4
Plant-Derived Synthetic
Humectant
Skin Conditioner
Synthetic
Clean
A natural sugar alcohol that draws moisture into skin and helps keep it hydrated and soft throughout the day.
Solubility greater than or equal to 100 mg/mL at 68 °F (NTP, 1992)
Formula
C6H14O6
Mol. Weight
182.17
CAS #
69-65-8
Form
Powder
See origin →
Functions
Binding
Humectant
A moisture magnet. Pulls water from the air and deeper skin layers up to the surface to keep skin plump and hydrated.
Moisturising
Skin Conditioning
A catch-all term for ingredients that improve how skin looks and feels — softer, smoother, more supple. The workhorse behind most moisturizers.
Locks In Moisture
Traditional Use
A naturally occurring sugar alcohol discovered in manna ash in the 17th century, first isolated and synthesized in the 19th century. Originally used as a sweetener before adoption in cosmetics as a humectant and anti-caking agent in the 20th century.
Skin Types
all-skin-types
Best For
Dehydration
Melanin-Rich Skin
Suitable
Pregnancy & Breastfeeding Safe
Yes
EWG
4
CIR
Safe
Pregnancy
Yes
CIR Safety Findings
medical-approval
all-shades-safe
Phototoxicity Concern
Regulatory Status
USApermitted
EUrestricted
JAPANrestricted
CANADArestricted
Safety Assessment of Mannitol, Sorbitol, and Xylitol as U...
Priya Cherian, Wilma F Bergfeld, Donald V Belsito, Curtis D Klaassen, Daniel C Liebler, James G Marks + 6 more
International journal of toxicology, 2025
Safety Assessment of Mannitol, Sorbitol and Xylitol as Used in Cosmetics
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
Mannitol
European Commission
EU Cosmetic Ingredient Database (CosIng)
Mannitol
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
Mannitol Is a Good Anticaking Agent for Spray-Dried Hydroxypropyl-Beta-Cyclodextrin Microcapsules.
Kou X, Zhang X, Cheng Y, Yu M, Meng Q et al.
Molecules (Basel, Switzerland), 2023
Glycyrrhizin and Mannitol Nasal Therapy: Cytological and ...
Giulio Pagliuca, Veronica Clemenzi, Salvatore Martellucci, Francesco Gazia, Sara Santarsiero, Luigi Farina + 2 more
International archives of otorhinolaryngology, 2023
Verified Feb 2026
Data: PubChem · CosIng · EWG · CIR