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N,N-Bis(2-Hydroxyethyl)-p-Phenylenediamine Sulfate
AKA “N-Bis(2-hydroxyethyl)-p-phenylenediamine sulphate, Ethanol, sulfate (1:1) (salt), COLOREX NNBIS, JAROCOL BHP, (p-Ammoniophenyl)bis(2-hydroxyethyl)ammonium sulphate”
Synthetic
Ingredient Facts
N,n-bis (2-Hydroxyethyl) -p-phenylenediamine sulfate
AKA: N-Bis(2-hydroxyethyl)-p-phenylenediamine sulphate, Ethanol, Sulfate (1:1) (salt), COLOREX NNBIS, JAROCOL BHP, (p-Ammoniophenyl)bis(2-hydroxyethyl)ammonium sulphate
Synthetic · Hair Dyeing · EWG: 4
Synthetic
Safety Concern
Synthetic
Clean
A color-depositing ingredient that helps permanent hair dyes bond to hair strands and develop rich, long-lasting color.
Formula
C10H18N2O6S
Mol. Weight
294.33
CAS #
54381-16-7
Form
Powder
See origin →
Functions
Hair Dyeing
Wound Healing
Moisturizing
Locks in moisture to keep skin soft and supple throughout the day
Strengthens Barrier
Colors hair
Traditional Use
A synthetic chemical dye intermediate developed in the 20th century for hair coloring applications. Part of the modern chemical oxidative hair dye system that replaced plant-based hair colorants.
Skin Types
●all-skin-types
Best For
General
Melanin-Rich Skin
Suitable
Pregnancy & Breastfeeding Safe
Caution
Allergen Warning
⚠️ PPD (Hair Dye)
EWG
4
CIR
Safe w/Qualifications
Pregnancy
Caution
CIR Safety Findings
medical-approval
all-shades-safe
Regulatory Status
USA✔ permitted
EU✔ permitted
JAPAN✔ permitted
CANADA✔ permitted
Final Amended Report on the Safety Assessment of 2,4-Diaminophenoxyethanol HCl and 2,4-Diaminophenoxyethanol Sulfate
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
Final Amended Report on the Safety Assessment of Ammonium Thioglycolate, Butyl Thioglycolate, Calcium Thioglycolate, Ethanolamine Thioglycolate, Ethyl Thioglycolate, Glyceryl Thioglycolate, Isooctyl T
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
Final Report on the Safety Assessment of 2,4-Diaminophenoxyethanol Dihydrochloride
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
Final Report on the Safety Assessment of 3-Methylamino-4-Nitrophenoxyethanol as Used in Hair Dyes
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
Final Report on the Safety Assessment of Butoxyethanol
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
Final Report on the Safety Assessment of Ethoxyethanol and Ethoxyethanol Acetate
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
Final Report on the Safety Assessment of Phenoxyethanol
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
Final Report on the Safety Assessment of Potassium-Coco-Hydrolyzed Animal Protein and Triethanolamine-Coco-Hydrolyzed Animal Protein
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
Final Report on the Safety Assessment of Triethanolamine, Diethanolamine, and Monoethanolamine
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
Final Report: Amended Safety Assessment of 2,4-Diaminophenoxyethanol HCl and 2,4-Diaminophenoxyethanol Sulfate as Used in Cosmetics
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
Re-evaluation: N,N-Bis(2-Hydroxyethyl)-p-Phenylenediamine Sulfate
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
Safety Assessment of Diethanolamides as Used in Cosmetics
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
Safety Assessment of Diethanolamine and Its Salts as Used in Cosmetics
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
Safety Assessment of Ethanolamides as Used in Cosmetics
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
Safety Assessment of Ethanolamine and Ethanolamine Salts as Used in Cosmetics
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
Safety Assessment of Triethanolamine and Triethanolamine-Containing Ingredients as Used in Cosmetics
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
Tentative Report: Amended Safety Assessment of Butoxyethanol as Used in Cosmetics
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
Phenoxyethanol Safety Assessment
Cosmetic Ingredient Review Expert Panel
International Journal of Toxicology, 2019
→
Safety review of phenoxyethanol when used as a preservati...
B Dréno, T Zuberbier, C Gelmetti, G Gontijo, M Marinovich
Journal of the European Academy of Dermatology and Venereology : JEADV, 2019
→
2,4-Diaminophenoxyethanol HCl
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
2,4-Diaminophenoxyethanol Sulfate
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Safety Assessment of Diethanolamine and Its Salts as Used...
Monice M Fiume, Bart Heldreth, Wilma F Bergfeld, Donald V Belsito, Ronald A Hill, Curtis D Klaassen + 6 more
International journal of toxicology, 2017
→
Safety Assessment of Diethanolamine and Its Salts as Used...
Monice M Fiume, Bart Heldreth, Wilma F Bergfeld, Donald V Belsito, Ronald A Hill, Curtis D Klaassen + 6 more
International journal of toxicology, 2017
→
Safety Assessment of Diethanolamine and Its Salts as Used...
Monice M Fiume, Bart Heldreth, Wilma F Bergfeld, Donald V Belsito, Ronald A Hill, Curtis D Klaassen + 6 more
International journal of toxicology, 2017
→
Verified Feb 2026
Data: PubChem · CosIng · EWG · CIR